Li Yubin, Li Chunlin, Jiang Lili
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Front Behav Neurosci. 2022 Mar 11;16:737121. doi: 10.3389/fnbeh.2022.737121. eCollection 2022.
Wellbeing refers to cognitive and emotional appraisal of an individual's life and social functioning, which is of great significance to the quality of life of an individual and society. Previous studies have revealed the neural basis of wellbeing, which mostly focused on human brain morphology or network-level connectivity. However, local-to-remote cortical connectivity, which plays a crucial role in defining the human brain architecture, has not been investigated in wellbeing. To examine whether wellbeing was associated with local-to-remote cortical connectivity, we acquired resting-state images from 60 healthy participants and employed the Mental Health Continuum Short Form to measure wellbeing, including three dimensions, namely, emotional wellbeing, psychological wellbeing, and social wellbeing. Functional homogeneity (ReHo) and seed-based functional connectivity were used to evaluate local-to-remote cortical connectivity in these participants. For local connectivity, our results showed that ReHo in the right orbitofrontal sulcus was significantly positively correlated with psychological wellbeing but negatively correlated with social wellbeing. For remote connectivity, connectivity within the right orbitofrontal cortex and interhemispheric connectivity of the orbitofrontal sulcus were both positively associated with psychological wellbeing; functional connectivity between the right orbitofrontal sulcus and the left postcentral sulcus was positively associated with social wellbeing. Our results showed that wellbeing was indeed associated with local-to-remote cortical connectivity, and our findings supplied a new perspective of distance-related neural mechanisms of wellbeing.
幸福感指的是个体对其生活和社会功能的认知与情感评估，这对个体和社会的生活质量具有重要意义。以往的研究揭示了幸福感的神经基础，这些研究大多聚焦于人类大脑形态或网络层面的连通性。然而，在幸福感研究中，尚未对在定义人类大脑结构方面起关键作用的局部到远程皮质连通性进行研究。为了检验幸福感是否与局部到远程皮质连通性相关，我们采集了60名健康参与者的静息态图像，并使用心理健康连续体简表来测量幸福感，该简表包括三个维度，即情绪幸福感、心理幸福感和社会幸福感。我们使用功能同质性（局部一致性，ReHo）和基于种子点的功能连通性来评估这些参与者的局部到远程皮质连通性。对于局部连通性，我们的结果显示，右侧眶额沟的局部一致性与心理幸福感呈显著正相关，但与社会幸福感呈负相关。对于远程连通性，右侧眶额皮质内的连通性以及眶额沟的半球间连通性均与心理幸福感呈正相关；右侧眶额沟与左侧中央后沟之间的功能连通性与社会幸福感呈正相关。我们的结果表明，幸福感确实与局部到远程皮质连通性相关，我们的研究结果为幸福感的距离相关神经机制提供了一个新的视角。
