Zhu Li, Chen Zhigang, Han Keli, Zhao Yilin, Li Yan, Li Dongxu, Wang Xiulong, Li Xuefang, Sun Siyu, Lin Fei, Zhao Guoan
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China.
Henan Joint International Research Laboratory of Cardiovascular Injury and Repair, Xinxiang, Henan, China.
Evid Based Complement Alternat Med. 2020 Oct 7;2020:2902136. doi: 10.1155/2020/2902136. eCollection 2020.
Cardiovascular disease (CVD) is the number one threat that seriously endangers human health. However, the mechanism of their occurrence is not completely clear. Increasing studies showed that mitochondrial dysfunction is closely related to CVD. Possible causes of mitochondrial dysfunction include oxidative stress, Ca disorder, mitochondrial DNA mutations, and reduction of mitochondrial biosynthesis, all of which are closely related to the development of CVD. At present, traditional Chinese medicine (TCM) is widely used in the treatment of CVD. TCM has the therapeutic characteristics of multitargets and multipathways. Studies have shown that TCM can treat CVD by protecting mitochondrial function. Via systematic literature review, the results show that the specific mechanisms include antioxidant stress, regulation of calcium homeostasis, antiapoptosis, and regulation of mitochondrial biosynthesis. This article describes the relationship between mitochondrial dysfunction and CVD, summarizes the TCM commonly used for the treatment of CVD in recent years, and focuses on the regulatory effect of TCM on mitochondrial function.
心血管疾病（CVD）是严重危害人类健康的首要威胁。然而，其发病机制尚不完全清楚。越来越多的研究表明，线粒体功能障碍与心血管疾病密切相关。线粒体功能障碍的可能原因包括氧化应激、钙紊乱、线粒体DNA突变和线粒体生物合成减少，所有这些都与心血管疾病的发展密切相关。目前，中医药广泛应用于心血管疾病的治疗。中医药具有多靶点、多途径的治疗特点。研究表明，中医药可通过保护线粒体功能来治疗心血管疾病。通过系统的文献综述，结果表明其具体机制包括抗氧化应激、调节钙稳态、抗凋亡和调节线粒体生物合成。本文阐述了线粒体功能障碍与心血管疾病之间的关系，总结了近年来常用于治疗心血管疾病的中医药，并重点探讨了中医药对线粒体功能的调节作用。
