Lin Fei, Chen Heng-Wen, Zhao Guo-An, Li Yan, He Xuan-Hui, Liang Wan-Qian, Shi Zhuo-Lin, Sun Si-Yu, Tian Pan-Pan, Huang Ming-Yan, Liu Chao
Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China.
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Evid Based Complement Alternat Med. 2020 Feb 17;2020:8048691. doi: 10.1155/2020/8048691. eCollection 2020.
There has been an increase in morbidity and mortality related to coronary heart disease (CHD) in China in recent years. Numerous clinical experiences and studies have shown that traditional Chinese medicine (TCM) plays an important role in the prevention, treatment, and prognosis of CHD. However, the mechanism of TCM in the treatment of CHD has not yet been elucidated. The circRNA-miRNA-mRNA network consists of miRNA that is competitively bound by circRNA, and miRNA regulates the transcription level of mRNA. Through literature review, we found that the circRNA-miRNA-mRNA network acts to contribute to certain effects to CHD such as myocardial hypertrophy, myocardial fibrosis, and heart failure. TCM contains constituents that act against CHD by antiatherosclerosis and apoptosis inhibition action, cardiac and cardiomyocyte protection, and these components also promote cell growth and protection of the vascular system by regulating miRNAs. Therefore, we consider that the circRNA-miRNA-mRNA network may be a new regulatory mechanism for the effective treatment of CHD by TCM.
近年来，中国冠心病（CHD）相关的发病率和死亡率有所上升。众多临床经验和研究表明，中医（TCM）在冠心病的预防、治疗及预后中发挥着重要作用。然而，中医治疗冠心病的机制尚未阐明。环状RNA-微小RNA-信使核糖核酸（circRNA-miRNA-mRNA）网络由circRNA竞争性结合的微小RNA（miRNA）组成，miRNA调节信使核糖核酸（mRNA）的转录水平。通过文献综述，我们发现circRNA-miRNA-mRNA网络对冠心病的某些效应如心肌肥大、心肌纤维化和心力衰竭有一定作用。中药含有通过抗动脉粥样硬化和抑制细胞凋亡作用、保护心脏和心肌细胞来对抗冠心病的成分，这些成分还通过调节微小RNA促进细胞生长和保护血管系统。因此，我们认为circRNA-miRNA-mRNA网络可能是中医有效治疗冠心病的一种新的调节机制。
