Department of Dental Prosthetics, Pomeranian Medical University, Szczecin, Poland.
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Dis Markers. 2020 Oct 12;2020:6351817. doi: 10.1155/2020/6351817. eCollection 2020.
The aim of this study was to investigate the role of rs1643821 and TNF- rs1800629 as potential genetic factors regulating anterior disc displacement without reduction-mediated inflammatory pathway.
The temporomandibular joint is a complex synovial joint that allows mandibular movement in three directions. Although temporomandibular disorders are widespread, limited data is available on the biochemical characteristics of the displaced disc and quality of the surrounding soft tissue. Changes in degenerative tissue provoke disc displacement which involves secretion of inflammatory markers and sequential conversion of fibroblast-like cells into chondrocyte-like cells. Due to the high occurrence in female adolescents, the potential role of sex hormones in temporomandibular joint disorders has been speculated. Furthermore, anterior disc displacement without reduction severely affects the quality of life.
124 Caucasian patients with a history of at least one anterior disc displacement without reduction within 3 months were enrolled. Anterior disc displacement without reduction was diagnosed based on clinical examination, diagnostic criteria (DC)/TMD, and cone-beam computed tomography/magnetic resonance imaging (CBCT/MRI). The control group consisted of 126 patients with no temporomandibular joint disorders. Genotyping of two single nucleotide polymorphisms, estrogen receptor 1 () rs1643821, and tumor necrosis factor (TNF-) rs1800629 was performed.
rs1643821 showed significant values (using chi-square analysis) revealing the difference in anterior disc displacement without reduction frequencies while TNF- rs1800629 polymorphism was found to be statistically insignificant when compared to the control group. Furthermore, patients with a genotype of rs1643821 showed a decreased probability (OR = 0.412) against anterior disc displacement without reduction when compared to the GG genotype (OR = 1).
rs1643821 with A allele frequency was lower in patients with anterior disc displacement without reduction compared to the control group. Thus, the rs1643821 variant is significantly associated with susceptibility to the anterior disc displacement without a reduction in European Caucasians. Conversely, TNF- rs1800629 was a statistically insignificant factor against anterior disc displacement without reduction when compared to the control group.
本研究旨在探讨 rs1643821 和 TNF- rs1800629 作为潜在的遗传因素在调节无复位的前盘移位中的作用。
颞下颌关节是一个复杂的滑膜关节，允许下颌在三个方向上运动。尽管颞下颌关节紊乱很常见，但关于移位盘的生化特征和周围软组织的质量的资料有限。退行性组织的变化引发了盘移位，涉及到炎症标志物的分泌和纤维母细胞样细胞向软骨细胞样细胞的连续转化。由于女性青少年的高发病率，人们推测性激素在颞下颌关节紊乱中的潜在作用。此外，无复位的前盘移位严重影响生活质量。
共纳入 124 例在 3 个月内至少有一次无复位的前盘移位病史的白种人患者。无复位的前盘移位是基于临床检查、诊断标准（DC）/TMD 和锥形束 CT/MRI 来诊断的。对照组由 126 例无颞下颌关节疾病的患者组成。对两种单核苷酸多态性，雌激素受体 1 () rs1643821 和肿瘤坏死因子 () rs1800629 进行基因分型。
rs1643821 显示出显著的差异（使用卡方分析），揭示了无复位的前盘移位频率的差异，而 TNF- rs1800629 多态性与对照组相比无统计学意义。此外，与 GG 基因型相比，rs1643821 基因型的患者发生无复位的前盘移位的概率降低（OR = 0.412）。
与对照组相比，无复位的前盘移位患者的 rs1643821 等位基因 A 的频率较低。因此，rs1643821 变异与欧洲白种人无复位的前盘移位的易感性显著相关。相反，与对照组相比，TNF- rs1800629 不是无复位的前盘移位的统计学上的显著因素。
