Kassem Zeinab, Sitarik Alexandra, Levin Albert M, Lynch Susan V, Havstad Suzanne, Fujimura Kei, Kozyrskyj Anita, Ownby Dennis R, Johnson Christine Cole, Yong Germaine J M, Wegienka Ganesa, Cassidy-Bushrow Andrea E
Department of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Department of Medicine, University of California, San Francisco, CA USA.
Matern Health Neonatol Perinatol. 2020 Oct 20;6:5. doi: 10.1186/s40748-020-00119-x. eCollection 2020.
Mounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examine associations between plasma 25-hydroxyvitamin D (25[OH]D) levels during pregnancy or at delivery (cord blood) and infant gut microbiota.
Maternal and cord blood 25[OH]D levels were assessed in a sample of pregnant women. Compositional analyses adjusted for race were run on the gut microbiota of their offspring at 1 and 6 months of age.
Mean prenatal 25(OH)D level was 25.04 ± 11.62 ng/mL and mean cord blood 25(OH)D level was 10.88 ± 6.77 ng/mL. Increasing prenatal 25(OH)D level was significantly associated with decreased richness ( = 0.028) and diversity ( = 0.012) of the gut microbiota at 1 month of age. Both prenatal and cord 25(OH)D were significantly associated with 1 month microbiota composition. A total of 6 operational taxonomic units (OTUs) were significantly associated with prenatal 25(OH)D level (four positively and two negatively) while 11 OTUs were significantly associated with cord 25(OH)D (10 positively and one negatively). Of these, OTU 93 () and OTU 210 () were consistently positively associated with maternal and cord 25(OH)D; OTU 64 () was positively associated with prenatal 25(OH)D but negatively associated with cord 25(OH)D.
Prenatal maternal and cord blood 25(OH)D levels are associated with the early life gut microbiota. Future studies are needed to understand how vitamin D and the microbiome may interact to influence child health.
越来越多的证据表明，维生素D和生命早期的肠道微生物群都会影响儿童的健康结局。然而，对于这两种重要的暴露因素之间的关系，我们却知之甚少。我们旨在研究孕期或分娩时（脐血）血浆25-羟基维生素D（25[OH]D）水平与婴儿肠道微生物群之间的关联。
对一组孕妇样本进行母体和脐血25[OH]D水平评估。对其后代1个月和6个月大时的肠道微生物群进行种族校正后的成分分析。
产前25(OH)D平均水平为25.04±11.62 ng/mL，脐血25(OH)D平均水平为10.88±6.77 ng/mL。产前25(OH)D水平升高与1个月大时肠道微生物群的丰富度降低（P = 0.028）和多样性降低（P = 0.012）显著相关。产前和脐血25(OH)D均与1个月时的微生物群组成显著相关。共有6个可操作分类单元（OTU）与产前25(OH)D水平显著相关（4个呈正相关，2个呈负相关），而11个OTU与脐血25(OH)D显著相关（10个呈正相关，1个呈负相关）。其中，OTU 93（P = 0.002）和OTU 210（P = 0.001）与母体和脐血25(OH)D始终呈正相关；OTU 64（P = 0.012）与产前25(OH)D呈正相关，但与脐血25(OH)D呈负相关。
产前母体和脐血25(OH)D水平与生命早期的肠道微生物群有关。未来需要开展研究，以了解维生素D和微生物群如何相互作用来影响儿童健康。
