Dai Yong, Guo Han, Chu Linyang, He Zihao, Wang Minqi, Zhang Shuhong, Shang Xifu
Shandong University, Jinan, 250012, Shandong, China.
Shanghai Institute of Applied Physics, CAS, 2019 Jialuo Road, Shanghai, 201800, China.
J Orthop Translat. 2019 Nov 21;24:198-208. doi: 10.1016/j.jot.2019.10.011. eCollection 2020 Sep.
To enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths.
Suspension coating and melt bonding.
Silicon nitride (SiN, SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid (SBF), which caused weak alkaline of micro-environment owing to the slight dissolution of SN; SN coating resulted in the improvements of adhesion, proliferation, differentiation and gene expressions of MC3T3-E1 cells ; SN coating of PEEK with bioactive SN coating (CSNPK) obviously promoted bone regeneration and osseointegration .
CSNPK with SN coating as bone implant might be a promising candidate for orthopedic implants.
The silicon nitride-coated polyetheretherketone (CSNPK) prepared in this article could induce MC3T3-E1 cells adhesion, proliferation and differentiation ; it could also induce bone regeneration in bone defect , which indicate its good cytocompatibility and biocompatibility. If the raw materials are medical grade, and preparation process as well as production process of this article are further improved, it will have great translational potential.
提高聚醚醚酮（PEEK）的生物活性，同时保持其机械强度。
悬浮涂层法和熔融粘结法。
氮化硅（SiN，SN）涂层导致更高的表面粗糙度、亲水性和蛋白质吸附；SN涂层可将Si离子缓慢释放到模拟体液（SBF）中，由于SN的轻微溶解导致微环境呈弱碱性；SN涂层导致MC3T3-E1细胞的粘附、增殖、分化及基因表达得到改善；具有生物活性SN涂层的PEEK（CSNPK）明显促进骨再生和骨整合。
具有SN涂层的CSNPK作为骨植入物可能是骨科植入物的一个有前景的候选者。
本文制备的氮化硅涂层聚醚醚酮（CSNPK）可诱导MC3T3-E1细胞粘附、增殖和分化；还可诱导骨缺损处的骨再生，表明其具有良好的细胞相容性和生物相容性。如果原材料为医用级，且本文的制备工艺以及生产工艺进一步改进，将具有很大的转化潜力。
