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全球范围内的 SARS-CoV-2 感染:感染人群估计和更高检出率如何拯救生命的衡量。

SARS-CoV-2 Infections in the World: An Estimation of the Infected Population and a Measure of How Higher Detection Rates Save Lives.

机构信息

Escuela de Ingeniería Comercial, Centro de Investigación en Economía Aplicada, Facultad de Economía y Negocios, Universidad de Talca, Talca, Chile.

出版信息

Front Public Health. 2020 Sep 25;8:489. doi: 10.3389/fpubh.2020.00489. eCollection 2020.

DOI:10.3389/fpubh.2020.00489
PMID:33102412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7545403/
Abstract

This paper provides an estimation of the accumulated detection rates and the accumulated number of infected individuals by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Worldwide, on July 20, it has been estimated above 160 million individuals infected by SARS-CoV-2. Moreover, it is found that only about 1 out of 11 infected individuals are detected. In an information context in which population-based seroepidemiological studies are not frequently available, this study shows a parsimonious alternative to provide estimates of the number of SARS-CoV-2 infected individuals. By comparing our estimates with those provided by the population-based seroepidemiological ENE-COVID study in Spain, we confirm the utility of our approach. Then, using a cross-country regression, we investigated if differences in detection rates are associated with differences in the cumulative number of deaths. The hypothesis investigated in this study is that higher levels of detection of SARS-CoV-2 infections can reduce the risk exposure of the susceptible population with a relatively higher risk of death. Our results show that, on average, detecting 5 instead of 35 percent of the infections is associated with multiplying the number of deaths by a factor of about 6. Using this result, we estimated that 120 days after the pandemic outbreak, if the US would have tested with the same intensity as South Korea, about 85,000 out of their 126,000 reported deaths could have been avoided.

摘要

本文对新型严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的累积检出率和感染人数进行了估计。截至 7 月 20 日,全球估计有超过 1.6 亿人感染了 SARS-CoV-2。此外,研究发现,只有约 11 分之一的感染者被检测到。在基于人群的血清流行病学研究不常有的信息背景下,本研究提供了一种简洁的替代方法来估计 SARS-CoV-2 感染人数。通过将我们的估计值与西班牙基于人群的血清流行病学 ENE-COVID 研究提供的估计值进行比较,我们证实了我们方法的有效性。然后,我们使用跨国回归分析,研究了检出率的差异是否与累积死亡人数的差异有关。本研究考察的假设是,更高水平的 SARS-CoV-2 感染检出率可以降低易感人群的风险暴露,而这些人群的死亡风险相对较高。我们的研究结果表明,平均而言,检测到 5%的感染而不是 35%的感染,会使死亡人数增加约 6 倍。根据这一结果,如果美国在大流行爆发后 120 天内,像韩国那样进行同样强度的检测,那么其报告的 12.6 万例死亡病例中,约有 8.5 万例是可以避免的。

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