Deng Youwen, Yang Youwen, Gao Chengde, Feng Pei, Guo Wang, He Chongxian, Chen Jian, Shuai Cijun
Department of Emergency Medicine, the Second Xiangya Hospital, Central South University, Changsha, China.
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, China.
Int J Bioprint. 2017 Nov 21;4(1):124. doi: 10.18063/IJB.v4i1.124. eCollection 2018.
It remains the primary issue to enhance the corrosion resistance of Mg alloys for their clinical applications. In this study, β-tricalcium phosphate (β-TCP) was composited with Mg-6Zn-1Zr (ZK60) using laser rapid solidification to improve the degradation behavior. Results revealed rapid solidification effectively restrained the aggregation of β-TCP, which thus homogenously distributed along grain boundaries of α-Mg. Significantly, the uniformly distributed β-TCP in the matrix promoted the formation of apatite layer on the surface, which contributed to the formation of a compact corrosion product layer, hence retarding the further degradation. Furthermore, ZK60/8β-TCP (wt. %) composite showed improved mechanical strength, as well as improved cytocompatibility. It was suggested that laser rapidly solidified ZK60/8β-TCP composite might be a potential materials for tissue engineering.
提高镁合金的耐腐蚀性仍然是其临床应用的首要问题。在本研究中，采用激光快速凝固法将β-磷酸三钙（β-TCP）与Mg-6Zn-1Zr（ZK60）复合，以改善其降解行为。结果表明，快速凝固有效地抑制了β-TCP的聚集，使其沿α-Mg的晶界均匀分布。值得注意的是，基体中均匀分布的β-TCP促进了表面磷灰石层的形成，这有助于形成致密的腐蚀产物层，从而延缓进一步降解。此外，ZK60/8β-TCP（重量百分比）复合材料的机械强度和细胞相容性均有所提高。研究表明，激光快速凝固ZK60/8β-TCP复合材料可能是一种潜在的组织工程材料。
