Shuai Cijun, Yang Youwen, Feng Pei, Peng Shuping, Guo Wang, Min Anjie, Gao Chengde
State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Jiangxi University of Science and Technology, Ganzhou 341000, China.
Int J Bioprint. 2018 Mar 31;4(2):133. doi: 10.18063/IJB.v4i2.133. eCollection 2018.
It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment. In this work, a novel combined process of additive manufacturing (AM) and chemical etching was developed to fabricate graphene oxide/poly(L-lactic acid) (GO/PLLA) scaffolds with multiscale porous structure. Specially, AM was used to fabricate an interconnected porous network with pore sizes of hundreds of microns. And the chemical etching in sodium hydroxide solution constructed pores with several microns or even smaller on scaffolds surface. The degradation period of the scaffolds was adjustable via controlling the size and quantity of pores. Moreover, the scaffolds exhibited surprising bioactivity after chemical etching, which was ascribed to the formed polar groups on scaffolds surfaces. Furthermore, GO improved the mechanical strength of the scaffolds.
开发一种用于精确控制支架互连多孔结构以模拟天然骨微环境的制造技术至关重要。在这项工作中，开发了一种新颖的增材制造（AM）与化学蚀刻相结合的工艺，以制造具有多尺度多孔结构的氧化石墨烯/聚（L-乳酸）（GO/PLLA）支架。具体而言，AM用于制造孔径为数百微米的互连多孔网络。而在氢氧化钠溶液中的化学蚀刻在支架表面构建了几微米甚至更小的孔隙。通过控制孔隙的尺寸和数量，支架的降解期是可调节的。此外，化学蚀刻后的支架表现出惊人的生物活性，这归因于支架表面形成的极性基团。此外，GO提高了支架的机械强度。
