线粒体中钙交换与信号传导的调控
Regulation of Ca exchanges and signaling in mitochondria.
作者信息
Carvalho Edmund J, Stathopulos Peter B, Madesh Muniswamy
机构信息
Department of Medicine, Centre for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX, 78228.
Department of Microbiology, Centre for Cellular Immunotherapies, University of Pennsylvania, Pennsylvania, 19104.
出版信息
Curr Opin Physiol. 2020 Oct;17:197-206. doi: 10.1016/j.cophys.2020.08.010. Epub 2020 Aug 23.
Abstract
Mitochondrial calcium (Ca) homeostasis also plays a key role in the buffering of cytosolic calcium (Ca) and calcium transported into the mitochondrial matrix regulates cellular metabolism, migration and cell fate decisions. Recent work has highlighted the importance of mCa homeostasis in regulating cellular function. The discovery of the mCa uptake complex has shed new light on the role of Ca dynamics in cytoskeletal remodeling, mitochondrial shape and motility in cellular dynamics. Here we attempt to decipher the vast landscape of calcium regulatory effects of the mitochondria, the underlying mechanisms and the dynamics that control cellular function.
摘要
线粒体钙（Ca）稳态在缓冲胞质钙（Ca）方面也起着关键作用，转运到线粒体基质中的钙调节细胞代谢、迁移和细胞命运决定。最近的研究突出了线粒体钙稳态在调节细胞功能中的重要性。线粒体钙摄取复合体的发现为钙动力学在细胞动力学中的细胞骨架重塑、线粒体形态和运动中的作用提供了新的线索。在此，我们试图解读线粒体钙调节作用的广阔图景、其潜在机制以及控制细胞功能的动力学。
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