Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.
Alcohol Alcohol. 2021 Apr 29;56(3):334-347. doi: 10.1093/alcalc/agaa097.
To compare effects on certain health indices in rodents of different doses of alcoholic beverages, huangjiu (Chinese yellow wine), red wine and baijiu (Chinese liquor) combined with high-fat diet (HFD) and the pure HFD.
A total of 80 rats were randomly divided into eight groups and treated with (a) basal diet (3.5 kcal/g); (b) HFD (19.5% w/w lard, 4.5 kcal/g) and (c) HFD with low or high doses of separate alcoholic beverages (2.5 and 5 g/kg ethanol, respectively) for 28 weeks.
Chronic drinking when combined with HFD was associated with reduced body weight, fat accumulation and serum TNF-α level, serum TG, TC and LDL-C levels, and improved glucose tolerance (OGTT) and insulin sensitivity (ITT), hepatic enzymes; elevated levels or activities of the antioxidant enzymes like superoxide dismutase, catalase and glutathione reductase, reduced the content of lipid peroxidation productions such as malondialdehyde, in comparison with the pure HFD intake. In addition, compared with HFD, drinking plus HFD improved microbiota dysbiosis, down-regulated the ratio of Firmicutes/Bacteroidetes and promoted the growth of some probiotics including Prevotellaceae_UCG-001 and norank_f__Bacteroidales_S24-7_group.
Overall, the three beverages showed different impacts on indicators but red wine showed the most 'beneficial' effects. Of course, higher ethanol dosages can be expected to cause overall negative health effects, and harms of high fat intake can be prevented by healthier diet.
比较不同剂量酒精饮料（黄酒、红酒和白酒）与高脂肪饮食（HFD）及单纯 HFD 结合对啮齿动物某些健康指标的影响。
将 80 只大鼠随机分为 8 组，分别给予（a）基础饮食（3.5 kcal/g）；（b）HFD（19.5% w/w 猪油，4.5 kcal/g）和（c）HFD 加低或高剂量的单独酒精饮料（分别为 2.5 和 5 g/kg 乙醇），共 28 周。
慢性饮酒与 HFD 联合使用可降低体重、脂肪堆积和血清 TNF-α水平、血清 TG、TC 和 LDL-C 水平，改善葡萄糖耐量（OGTT）和胰岛素敏感性（ITT），降低肝酶；提高抗氧化酶如超氧化物歧化酶、过氧化氢酶和谷胱甘肽还原酶的水平或活性，降低丙二醛等脂质过氧化产物的含量，与单纯 HFD 摄入相比。此外，与 HFD 相比，饮酒加 HFD 改善了微生物失调，降低了厚壁菌门/拟杆菌门的比例，并促进了一些益生菌的生长，包括普雷沃氏菌科 UCG-001 和未分类的拟杆菌目 S24-7 组。
总的来说，三种饮料对各项指标的影响不同，但红酒的效果最为“有益”。当然，较高的乙醇剂量可能会对整体健康产生负面影响，而通过更健康的饮食可以预防高脂肪摄入的危害。
