Department of Chemistry, College of Natural Sciences, Makerere University, Kampala, Uganda.
Department of Chemistry, School of Physical Sciences, University of Nairobi, Nairobi, Kenya.
Nat Prod Res. 2022 May;36(9):2321-2328. doi: 10.1080/14786419.2020.1833201. Epub 2020 Oct 24.
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-benzylcarvotacetone (), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl--benzoquinone () and piperitol ()) were prepared to provide ()-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (), 3-hydroxypiperitone () and carvacrol (). Structure of was determined based on NMR and HRMS spectral data. Compound exhibited activity against fungi with an IC value of < 0.8µg/mL. In addition, this compound had an IC value of 14.97µg/mL against methicillin resistant bacteria. Previous to the current study, both compound and had been reported to have anti-microbial and anti-fungal activities.
单萜衍生物在制药行业具有重要的生物学意义。在本研究中，制备了卡瓦酮的吡咯烷衍生物 3-苄基卡瓦酮（）和选定的单萜（3-羟基-2-异丙基-5-甲基-1,4-苯醌（）和哌啶醇（）），以提供（）-1-（4-（苄氧基）-5-异丙基-2-甲基环己烷-1,3-二烯-1-基）-吡咯烷（），2-异丙基-5-甲基-3,6-二氧代环己烷-1,4-二烯-1-基乙酸酯（），3-羟基哌啶酮（）和香芹酚（）。根据 NMR 和 HRMS 光谱数据确定了化合物的结构。化合物 对真菌表现出活性，IC 值<0.8µg/mL。此外，该化合物对耐甲氧西林的细菌的 IC 值为 14.97µg/mL。在当前研究之前，化合物 和 均已被报道具有抗微生物和抗真菌活性。
