Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant and anti-cryptococcal properties.

Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-benzylcarvotacetone (), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl--benzoquinone () and piperitol ()) were prepared to provide ()-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (), 3-hydroxypiperitone () and carvacrol (). Structure of was determined based on NMR and HRMS spectral data. Compound exhibited activity against fungi with an IC value of < 0.8µg/mL. In addition, this compound had an IC value of 14.97µg/mL against methicillin resistant bacteria. Previous to the current study, both compound and had been reported to have anti-microbial and anti-fungal activities.