倍半萜和单萜类化合物从叶子和茎和他们的抗菌活性。

Sesquiterpenes and Monoterpenes from the Leaves and Stems of and Their Antibacterial Activity.

机构信息

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China.

School of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

出版信息

Molecules. 2022 Feb 8;27(3):1115. doi: 10.3390/molecules27031115.

Two undescribed ether derivatives of sesquiterpenes, 1-ethoxycaryolane-1, 9-diol () and 2-ethoxyclovane-2, 9-diol (), and one new monoterpene glycoside, p-menthane-1,2,8-triol-4-O--D-glucoside (), were obtained, together with eight known compounds from the stems and leaves of . Their structures were elucidated by spectroscopic methods. Compounds - were evaluated for their potency against and clinical methicillin-resistant (MRSA). Among them, compound was weakly active against (MIC = 128 μg/mL), and compounds and exhibited good antibacterial activity against and MRSA (MICs = 2-8 µg/mL). A primary mechanism study revealed that compounds and could kill bacteria by destroying bacterial cell membranes. Moreover, compounds and were not susceptible to drug resistance development.

从滇丁香的茎叶中分离得到了两个未被描述的倍半萜醚类衍生物

1-乙氧基蒈烷-1,9-二醇（）和 2-乙氧基环戊烷-2,9-二醇（），以及一个新的单萜糖苷 p-薄荷烷-1,2,8-三醇-4-O--D-葡萄糖苷（），此外还分离得到了 8 个已知化合物。通过波谱方法鉴定了它们的结构。对这些化合物的抗菌活性进行了评价，包括对和临床耐甲氧西林金黄色葡萄球菌（MRSA）的抑制作用。结果表明，化合物 - 对（MIC = 128 μg/mL）表现出较弱的抑制活性，而化合物、对、MRSA 均具有较好的抗菌活性（MICs = 2-8 μg/mL）。初步的机制研究表明，化合物、能够通过破坏细菌细胞膜来杀死细菌。此外，化合物、不易产生耐药性。