Chernyshov Vladimir V, Popadyuk Irina I, Yarovaya Olga I, Salakhutdinov Nariman F
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrent'ev av., 9, Novosibirsk, 630090, Russian Federation.
Novosibirsk State University, Pirogova St. 1, 630090, Novosibirsk, Russian Federation.
Top Curr Chem (Cham). 2022 Aug 11;380(5):42. doi: 10.1007/s41061-022-00399-1.
Directed transformation of available natural compounds with native biological activity is a promising area of research in organic and medicinal chemistry aimed at finding effective drug substances. The number of scientific publications devoted to the transformation of natural compounds and investigations of their pharmacological properties, in particular, monoterpenes and their nearest derivatives, increases every year. At the same time, the chemistry of nitrogen-containing heterocyclic compounds has been actively developed since the 1950s after the news that the benzimidazole core is an integral part of the structure of vitamin B. At the time of writing this review, the data on chemical modifications of monoterpenes and their nearest derivatives leading to formation of compounds with a nitrogen-containing heterocycle core have not been summarized and systematized in terms of chemical transformations. In this review, we tried to summarize the literature data on the preparation and properties of nitrogen-containing heterocyclic compounds synthesized from monoterpenes/monoterpenoids and their nearest derivatives for the period from 2000 to 2021.
将具有天然生物活性的可用天然化合物进行定向转化，是有机化学和药物化学中一个很有前景的研究领域，旨在寻找有效的药物物质。致力于天然化合物转化及其药理性质研究的科学出版物数量逐年增加，特别是单萜及其最接近的衍生物。与此同时，自20世纪50年代有消息称苯并咪唑核心是维生素B结构的一个组成部分以来，含氮杂环化合物的化学领域得到了积极发展。在撰写本综述时，关于单萜及其最接近的衍生物的化学修饰导致形成含氮杂环核心化合物的数据，尚未根据化学转化进行总结和系统化。在本综述中，我们试图总结2000年至2021年期间由单萜/单萜类化合物及其最接近的衍生物合成的含氮杂环化合物的制备和性质的文献数据。
