Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Adv Exp Med Biol. 2013;756:113-9. doi: 10.1007/978-94-007-4549-0_15.
Obstructive sleep apnea (OSA) is an independent risk factor in the pathogenesis of -cardiovascular diseases. The aim of the study was to analyze three specific adhesion molecules involved in the development of an atherosclerotic plaque: E-selectin (endothelium), L-selectin (leukocyte surface), and P-selectin (from platelet), circulating in plasma in patients at different OSA severity. Eighty non-smoking male Caucasians aged 30-64 were enrolled into the study after clinical, biochemical, and polysomnographic examinations. The patients were divided into four groups based on the results of apnea/hypopnea index (AHI): OSA-0 with AHI 0-4.9 (n = 20), OSA-1 with AHI 5-15 (n = 21), OSA-2 with AHI 16-30 (n = 18), OSA-3 with AHI ≥ 31 (n = 21). Complete blood count, oral glucose tolerance test, fasting lipid profile, C-reactive protein and insulin, and plasma concentrations of soluble E-selectin, P-selectin and L-selectin were measured. We found a progressive increase in the concentrations of all three selectins with the severity of OSA. In conclusion, the level of plasma adhesion molecules may be indicative of OSA severity and may contribute to cardiovascular sequelae.
阻塞性睡眠呼吸暂停（OSA）是心血管疾病发病机制中的一个独立危险因素。本研究旨在分析三种与动脉粥样硬化斑块形成有关的特定黏附分子：E-选择素（内皮细胞）、L-选择素（白细胞表面）和 P-选择素（血小板），它们在不同严重程度 OSA 患者的血浆中循环。经过临床、生化和多导睡眠图检查，我们招募了 80 名不吸烟的 30-64 岁高加索男性白人患者入组。根据呼吸暂停/低通气指数（AHI）的结果，患者被分为四组：OSA-0 组（AHI 0-4.9，n = 20）、OSA-1 组（AHI 5-15，n = 21）、OSA-2 组（AHI 16-30，n = 18）和 OSA-3 组（AHI ≥ 31，n = 21）。测量了全血细胞计数、口服葡萄糖耐量试验、空腹血脂谱、C 反应蛋白和胰岛素以及血浆可溶性 E-选择素、P-选择素和 L-选择素浓度。我们发现，随着 OSA 严重程度的增加，三种选择素的浓度均呈逐渐升高趋势。总之，血浆黏附分子的水平可能提示 OSA 的严重程度，并可能导致心血管并发症。
