Greenough A, Wood S, Morley C J, Davis J A
Lancet. 1984 Jan 7;1(8367):1-3. doi: 10.1016/s0140-6736(84)90177-6.
Preterm infants who were making expiratory efforts against ventilator inflation were randomised to be paralysed with pancuronium or to receive no paralysing agent during ventilation. Pneumothoraces developed in all 11 unparalysed babies but in only 1 of 11 (p less than 0.0004) of those managed with pancuronium, which had no serious side-effects. In 34 infants excluded from the trial because they were not breathing against the ventilator, no pneumothoraces developed.
在呼吸机充气时进行呼气努力的早产儿被随机分为两组，一组用泮库溴铵使其麻痹，另一组在通气期间不使用麻痹剂。11名未使用麻痹剂的婴儿均发生了气胸，但在使用泮库溴铵治疗的11名婴儿中仅1例发生气胸（P<0.0004），且泮库溴铵无严重副作用。在因未对抗呼吸机呼吸而被排除在试验之外的34名婴儿中，未发生气胸。
