Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
J Strength Cond Res. 2020 Nov;34(11):3037-3041. doi: 10.1519/JSC.0000000000003750.
Homma, H, Kobatake, N, Sekimoto, Y, Saito, M, Mochizuki, Y, Okamoto, T, Nakazato, K, Nishiyama, T, and Kikuchi, N. Ciliary neurotrophic factor receptor rs41274853 polymorphism is associated with weightlifting performance in Japanese weightlifters. J Strength Cond Res 34(11): 3037-3041, 2020-At least 69 genetic markers are associated with power athlete status. In the present study, we investigated the genotype frequency of the ciliary neurotrophic factor receptor (CNTFR) rs41274853 polymorphism and the association between specific CNTFR genotype and weightlifting performance in Japanese weightlifters. One hundred sixty-five Japanese weightlifters (103 men and 62 women) and 338 controls (122 men and 216 women) participated in the present case-control study. Saliva samples were collected using the Oragene DNA self-collection kit and genotyping for the CNTFR (rs41274853) polymorphism was performed using the TaqMan assay. A questionnaire, noting each subject's best record in an official weightlifting competition, was used to obtain the weightlifting performance. The frequencies of the CNTFR genotypes CC, CT, and TT were 56, 32, 12% in the weightlifters, and 53, 40, and 7% in the controls, respectively. There was no significant difference in CNTFR genotype frequencies between the weightlifters and controls. However, the frequency of the CT + TT genotype was significantly higher in international-level weightlifters than in the national-level weightlifters. The relative value per body weight of snatch, clean, and jerk, and total record were significantly higher in the athletes with CT + TT genotype than in the athletes with CC genotype (p < 0.05). Our results suggest that the CNTFR rs41274853 CT + TT genotype is associated with weightlifting performance in Japanese weightlifters. The CNTFR rs41274853 polymorphism may enable coaches to develop tailor-made training programs for individual athletes. In addition, strength and conditioning coaches could benefit from genetic information when assessing potential athletic talents and creating strength training programs for their athletes.
Homma 等人研究了睫状神经营养因子受体（CNTFR）rs41274853 多态性的基因型频率，以及特定 CNTFR 基因型与日本举重运动员举重表现之间的关系。在本研究中，我们调查了 CNTFR(rs41274853)多态性的基因型频率，以及特定 CNTFR 基因型与日本举重运动员举重表现之间的关系。165 名日本举重运动员（103 名男性和 62 名女性）和 338 名对照者（122 名男性和 216 名女性）参加了本病例对照研究。使用 Oragene DNA 自我采集试剂盒采集唾液样本，并使用 TaqMan 检测法对 CNTFR(rs41274853)多态性进行基因分型。使用问卷记录每位受试者在官方举重比赛中的最佳成绩，以获得举重表现。CNTFR 基因型 CC、CT 和 TT 的频率分别为举重运动员中的 56%、32%和 12%，对照组中的 53%、40%和 7%。举重运动员和对照组之间 CNTFR 基因型频率无显著差异。然而，国际级举重运动员中 CT+TT 基因型的频率明显高于国家级举重运动员。CT+TT 基因型运动员的抓举、挺举和总成绩的相对体重值明显高于 CC 基因型运动员（p<0.05）。我们的结果表明，CNTFR rs41274853 CT+TT 基因型与日本举重运动员的举重表现有关。CNTFR rs41274853 多态性可能使教练能够为个别运动员制定量身定制的训练计划。此外，力量和体能教练在评估潜在的运动天赋和为运动员制定力量训练计划时，可以从遗传信息中受益。
