Seki Shotaro, Kobayashi Tetsuro, Beppu Kenji, Nojo Manabu, Hoshina Kosaku, Kikuchi Naoki, Okamoto Takanobu, Nakazato Koichi, Hwang Inkwan
Faculty of Sport Science, Nippon Sport Science University, 7-1-1, Fukasawa, Setagaya-ku 158-8508, Japan.
LOGISTEED Track & Field Club House, LOGISTEED, Ltd., Hachigasakimidori-cho, Matsudo-shi 270-0024, Japan.
Genes (Basel). 2024 Dec 19;15(12):1627. doi: 10.3390/genes15121627.
BACKGROUND/OBJECTIVES: Monocarboxylate transporters (MCTs) comprise 14 known isoforms, with MCT1 being particularly important for lactate transport. Variations in lactate metabolism capacity and aerobic performance are associated with the T1470A polymorphism in . We aimed to investigate the frequency of the T1470A polymorphism and compare relevant physiological parameters among long-distance runners, wherein these parameters are fundamental to athletic performance.
We included 158 Japanese long-distance runners (LD) and 649 individuals from the general Japanese population (CON). The frequency of the T1470A polymorphism was compared between these groups and across athletic levels using the chi-square test. Additionally, physiological data were collected from 57 long-distance runners, and respiratory gas measurements were obtained using the mixing-chamber method during a graded incremental exercise test.
We observed a significant difference between the LD and CON groups in the dominant model and between the sub-28 min group and 28 min or above group in the recessive model. As the competitive level increased, the frequency of the AA genotype also increased. When comparing physiological parameters between the AA genotype and T allele, subjects with the AA genotype showed significantly higher values for oxygen uptake at lactate threshold ( = 0.001), oxygen uptake at onset of blood lactate accumulation ( = 0.01), maximal oxygen uptake ( = 0.005), and maximal blood lactate concentration ( = 0.038).
These results suggest that the AA genotype of the T1470A polymorphism of is an effective genotype associated with athletic status and aerobic capacity in Japanese long-distance runners.
背景/目的：单羧酸转运体（MCTs）由14种已知亚型组成，其中MCT1对乳酸转运尤为重要。乳酸代谢能力和有氧能力的变化与[具体基因名称]中的T1470A多态性相关。我们旨在研究T1470A多态性的频率，并比较长跑运动员之间的相关生理参数，因为这些参数对运动表现至关重要。
我们纳入了158名日本长跑运动员（LD）和649名日本普通人群（CON）。使用卡方检验比较了这些组之间以及不同运动水平的T1470A多态性频率。此外，从57名长跑运动员中收集了生理数据，并在分级递增运动试验中使用混合室法进行了呼吸气体测量。
我们观察到在显性模型中LD组和CON组之间存在显著差异，在隐性模型中28分钟以内组和28分钟及以上组之间存在显著差异。随着竞争水平的提高，AA基因型的频率也增加。当比较AA基因型和T等位基因之间的生理参数时，AA基因型的受试者在乳酸阈值时的摄氧量（P = 0.001）、血乳酸积累开始时的摄氧量（P = 0.01）、最大摄氧量（P = 0.005）和最大血乳酸浓度（P = 0.038）方面显示出显著更高的值。
这些结果表明，[具体基因名称]的T1470A多态性的AA基因型是与日本长跑运动员的运动状态和有氧能力相关的有效基因型。
