Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Expert Rev Respir Med. 2021 Mar;15(3):393-401. doi: 10.1080/17476348.2021.1842203. Epub 2020 Dec 3.
: To assess the patterns and trends of influenza and pneumonia-attributed deaths among cancer patients in the United States.: Surveillance, Epidemiology and End Results (SEER) database was accessed and cancer patients diagnosed 1975-2016 who have been included in the SEER-9 registries were included. The primary endpoint of the study is standardized mortality rate (SMR; calculated as observed/ Expected (O/E) ratio for death from influenza and pneumonia among cancer patients).: The current study evaluates a total of 3,579,199 cancer patients (diagnosed 1975-2016) within the SEER-9 registries; and influenza and pneumonia-attributed deaths represent 1.5% of the recorded deaths for this cohort. SMR for influenza/ pneumonia-attributed death within the first year following cancer diagnosis was 1.88 (1.83-1.94);while SMR for influenza/pneumonia-attributed death following the first year was 1.11 (1.10-1.12). Within the first year following cancer diagnosis, SMR from influenza/pneumonia was higher among individuals with black race (SMR for white race: 1.75 (95% CI: 1.69-1.81) while SMR for black race: 2.90 (95% CI: 2.65-3.16), lung cancer (SMR for lung cancer: 4.39 (95% CI: 4.11-4.69)), head and neck cancer (SMR for oral cavity/ pharynx cancer: 4.02 (95% CI: 3.50-4.59)), lymphomas (SMR for lymphoma: 3.28 (95% CI: 2.92-3.68)), leukemias (SMR for leukemia: 3.32 (95% CI: 2.89-3.80)) and myeloma (SMR for myeloma: 3.91 (95% CI: 3.28-4.63)).: Cancer patients are more likely to have influenza/ pneumonia-attributed death compared to the general US population. This risk is higher among patients with lung cancer, head and neck cancer, and hematological malignancies.
利用监测、流行病学和最终结果（SEER）数据库，纳入了 1975 年至 2016 年间被纳入 SEER-9 登记处的诊断为癌症的患者。本研究的主要终点是标准化死亡率（SMR；计算为癌症患者因流感和肺炎死亡的观察/预期（O/E）比值）。本研究共评估了 SEER-9 登记处的 3579199 例癌症患者（1975 年至 2016 年诊断）；在该队列中，流感和肺炎相关死亡占记录死亡人数的 1.5%。癌症诊断后第一年因流感/肺炎导致的死亡的 SMR 为 1.88（1.83-1.94）；而在第一年之后，因流感/肺炎导致的死亡的 SMR 为 1.11（1.10-1.12）。在癌症诊断后的第一年，黑种人群的流感/肺炎 SMR 高于白种人群（白种人群的 SMR 为 1.75（95%CI：1.69-1.81），而黑种人群的 SMR 为 2.90（95%CI：2.65-3.16）），肺癌（肺癌的 SMR 为 4.39（95%CI：4.11-4.69）），头颈部癌症（口腔/咽癌的 SMR 为 4.02（95%CI：3.50-4.59）），淋巴瘤（淋巴瘤的 SMR 为 3.28（95%CI：2.92-3.68）），白血病（白血病的 SMR 为 3.32（95%CI：2.89-3.80））和骨髓瘤（骨髓瘤的 SMR 为 3.91（95%CI：3.28-4.63））。与一般美国人群相比，癌症患者更有可能因流感/肺炎而死亡。这种风险在肺癌、头颈部癌症和血液恶性肿瘤患者中更高。
