Bagwe Shreya, Gopalakrishnan D, Mehta Vini, Mathur Ankita, Kapare Krutika, Deshpande Apeksha
Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Indian J Dent Res. 2020 Jul-Aug;31(4):520-525. doi: 10.4103/ijdr.IJDR_796_18.
Omentin is an adipocytokine secreted by visceral adipose tissue cells associated with the action of insulin-increasing, insulin-facilitated glucose uptake.
The aim of this study was to compare and evaluate the levels of omentin in gingival crevicular fluid (GCF) and serum of periodontally healthy individuals and chronic periodontitis (CP) patients with and without type 2 diabetes mellitus (T2DM).
A hospital-based comparative study was conducted amongst 40 subjects of age group 30-50 years.
Subjects were divided into four groups, group I (10 healthy individuals), group II (10 T2DM), group III (10 CP only) and group IV (10 patients with CP and T2DM). Clinical and systemic parameters assessed were gingival index (GI), plaque index (PI), probing pocket depth (PPD), periodontal attachment level (PAL) and glycated haemoglobin (HbA). Serum and GCF samples were collected and analysed for omentin levels using the enzyme-linked immunosorbent assay (ELISA).
Although the mean GCF omentin levels were highest in group I and lowest in group IV, it was not statistically significant. However, the serum omentin levels were statistically significant, showing the highest mean level in group I and lowest in group IV and serum levels were statistically significant. Also, the serum omentin levels had a negative correlation with HbA.
The levels of omentin reflect the diabetic status of an individual, which suggests that omentin can be a potential anti-inflammatory marker and a therapeutic agent for conditions like CP and T2DM.
网膜素是一种由内脏脂肪组织细胞分泌的脂肪细胞因子，与增加胰岛素作用、促进胰岛素介导的葡萄糖摄取有关。
本研究旨在比较和评估牙周健康个体以及患有和未患有2型糖尿病（T2DM）的慢性牙周炎（CP）患者龈沟液（GCF）和血清中网膜素的水平。
在40名年龄在30至50岁之间的受试者中进行了一项基于医院的对比研究。
受试者分为四组，第一组（10名健康个体），第二组（10名T2DM患者），第三组（10名仅患有CP的患者）和第四组（10名患有CP和T2DM的患者）。评估的临床和全身参数包括牙龈指数（GI）、菌斑指数（PI）、探诊袋深度（PPD）、牙周附着水平（PAL）和糖化血红蛋白（HbA）。收集血清和GCF样本，并使用酶联免疫吸附测定（ELISA）分析网膜素水平。
尽管平均GCF网膜素水平在第一组中最高，在第四组中最低，但差异无统计学意义。然而，血清网膜素水平差异具有统计学意义，显示第一组平均水平最高，第四组最低，且血清水平差异具有统计学意义。此外，血清网膜素水平与HbA呈负相关。
网膜素水平反映个体的糖尿病状态，这表明网膜素可能是一种潜在的抗炎标志物以及用于CP和T2DM等病症的治疗剂。
