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日本一家精神病院使用丁丙诺啡进行海洛因脱毒的回顾性分析。

Retrospective analysis of heroin detoxification with buprenorphine in a psychiatric hospital in Japan.

机构信息

Department of Psychiatry, Fukko-kai Tarumi Hospital, Kobe, Japan.

Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan.

出版信息

Neuropsychopharmacol Rep. 2020 Dec;40(4):376-382. doi: 10.1002/npr2.12147. Epub 2020 Oct 27.

DOI:10.1002/npr2.12147
PMID:33107693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7722651/
Abstract

AIM

We assessed the efficacy of buprenorphine replacement taper therapy in a psychiatric hospital in Japan.

METHODS

Based on the medical records, a retrospective analysis was performed to evaluate the outcomes of buprenorphine replacement taper therapy in 106 subjects with heroin dependence.

RESULTS

We found that replacement and taper therapy with buprenorphine could significantly reduce withdrawal symptoms during detoxification. In addition, the completion rate of detoxification was significantly improved and the length of hospital stay was significantly reduced relative to those who received conventional treatment without buprenorphine. However, the readmission rate increased after the introduction of detoxication therapy with buprenorphine.

CONCLUSION

The present findings suggest not only the efficacy and safety of buprenorphine replacement and taper therapy, but also the requirement for maintenance therapy for individuals with heroin dependence.

摘要

目的

我们评估了丁丙诺啡替代递减疗法在日本一家精神病院的疗效。

方法

基于病历资料，我们进行了一项回顾性分析，以评估 106 例海洛因依赖者接受丁丙诺啡替代递减疗法的结局。

结果

我们发现，丁丙诺啡替代递减疗法可显著减轻脱毒过程中的戒断症状。此外，与未使用丁丙诺啡的常规治疗相比，丁丙诺啡替代递减疗法可显著提高脱毒完成率，并显著缩短住院时间。然而，在引入丁丙诺啡脱毒治疗后，再入院率增加。

结论

本研究结果不仅表明丁丙诺啡替代递减疗法具有疗效和安全性，还提示需要对海洛因依赖者进行维持治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/9848348de814/NPR2-40-376-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/dfaf51a6697f/NPR2-40-376-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/55c4dfab4f32/NPR2-40-376-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/9848348de814/NPR2-40-376-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/dfaf51a6697f/NPR2-40-376-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/55c4dfab4f32/NPR2-40-376-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fdb/7722651/9848348de814/NPR2-40-376-g003.jpg

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