外用干扰素治疗生殖器疱疹。
Therapy of genital herpes with topically applied interferon.
作者信息
Eron L J, Toy C, Salsitz B, Scheer R R, Wood D L, Nadler P I
机构信息
Division of Infectious Diseases, Fairfax Hospital, Falls Church, Virginia 22046.
出版信息
Antimicrob Agents Chemother. 1987 Jul;31(7):1137-9. doi: 10.1128/AAC.31.7.1137.
Abstract
Ninety-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive topical therapy for 5 days with either alpha-2a interferon at 30 X 10(6) IU/ml or 10 X 10(6) IU/ml or placebo six times daily. No differences were noted between either interferon dose and placebo with respect to the duration of viral shedding, the time to crusting, or the time to healing of herpetic lesions. Aqueous solutions of alpha-2a interferon applied topically to unroofed vesicles do not appear to be clinically useful in the treatment of recurrences of genital herpes.
摘要
94例复发性生殖器疱疹患者在一项双盲试验中被随机分组，接受为期5天的局部治疗，每天6次，分别使用浓度为30×10⁶IU/ml或10×10⁶IU/ml的α-2a干扰素或安慰剂。在病毒排出持续时间、结痂时间或疱疹皮损愈合时间方面，两种干扰素剂量与安慰剂之间均未发现差异。局部应用于未破损水疱的α-2a干扰素水溶液似乎对复发性生殖器疱疹的治疗无临床疗效。
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