唇疱疹的发病机制：水疱液干扰素与病损年龄和病毒滴度的相关性
Pathogenesis of herpes simplex labialis: correlation of vesicle fluid interferon with lesion age and virus titer.
作者信息
Spruance S L, Green J A, Chiu G, Yeh T J, Wenerstrom G, Overall J C
出版信息
Infect Immun. 1982 Jun;36(3):907-10. doi: 10.1128/iai.36.3.907-910.1982.
Abstract
Of 51 patients with herpes simplex labialis, 50 had detectable interferon (IFN) in samples of lesion vesicle fluid. The median titer of vesicle fluid IFN was 8,200 U. and the range of values was 400 to 63,600 U. The amount of vesicle fluid IFN was correlated with lesion age (r = 0.32, P = 0.024) and vesicle fluid virus titer (r = 0.59, P = 0.00004), but not with the clinical severity of the disease. The presence of vesicle fluid IFN (1,500 to 28,600 U) in 15 lesions less than 12 h old emphasizes the need for early treatment in studies of antiviral agents for herpes simplex labialis.
摘要
在51例唇疱疹患者中，50例病变水疱液样本中可检测到干扰素（IFN）。水疱液IFN的中位滴度为8200 U，取值范围为400至63600 U。水疱液IFN的量与病变年龄（r = 0.32，P = 0.024）和水疱液病毒滴度（r = 0.59，P = 0.00004）相关，但与疾病的临床严重程度无关。15个病程小于12小时的病变中存在水疱液IFN（1500至28600 U），这强调了在唇疱疹抗病毒药物研究中进行早期治疗的必要性。
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