Geriatric Medicine, Northern Jiangsu People's Hospital, Yangzhou, China.
Department of Laboratory Medicine, Clinical Medical College of Yangzhou University, Yangzhou, China.
Cancer Med. 2020 Dec;9(23):9096-9106. doi: 10.1002/cam4.3497. Epub 2020 Oct 27.
Gastric cancer is the third leading cause of cancer-related deaths worldwide. Novel biomarkers circRNAs can play an important role in the development of gastric cancer as oncogenes or tumor suppressor genes. The purpose of this study was to clarify the relationship between the abnormal expression of multiple circRNAs and their prognostic value in gastric cancer patients through a meta-analysis. We researched articles reporting the relationship between circRNAs and the prognosis of gastric cancer published in PubMed, Cochrane, Embase, Web of Science, Wanfang, CNKI, and VIP databases before 31 December 2019. Thirty-five articles were selected for the meta-analysis, involving 3135 gastric cancer patients. The total HR values (95% CI) of OS and DFS related to highly expressed circRNAs that indicated worse prognosis were 1.83 (1.64-2.03; p < 0.001) and 1.66 (1.33-2.07; p < 0.001), respectively. The total HR (95% CI) of OS and DFS related to highly expressed circRNAs that indicated better prognosis was 0.54 (0.45-0.66; p < 0.001) and 0.58 (0.43-0.78; p < 0.001), respectively. Two panels of five circRNAs predicted a more considerable HR value (circ_0009910, hsa_circ_0000467, hsa_circ_0065149, hsa_circ_0081143, and circDLST; and circSMARCA5, circLMTK2, hsa_circ_0001017, hsa_circ_0061276, and circ-KIAA1244). The results of the meta-analysis were 2.63 (2.08-3.33; p < 0.001) and 0.39 (0.27-0.59; p < 0.001) for OS, respectively. The two panels of dysregulated circRNAs can be considered as more suitable potential prognostic tumor biomarkers in patients with gastric cancer because of their larger HR values.
胃癌是全球癌症相关死亡的第三大主要原因。新型生物标志物 circRNAs 可以作为癌基因或肿瘤抑制基因，在胃癌的发展中发挥重要作用。本研究通过荟萃分析旨在阐明多个 circRNAs 异常表达与胃癌患者预后之间的关系。我们检索了 2019 年 12 月 31 日前在 PubMed、Cochrane、Embase、Web of Science、万方、中国知网和 VIP 数据库中发表的报道 circRNAs 与胃癌预后关系的文章。共纳入 35 项研究进行荟萃分析，涉及 3135 例胃癌患者。高表达预示预后不良的 circRNAs 与 OS 和 DFS 相关的总 HR 值（95%CI）分别为 1.83（1.64-2.03;p<0.001）和 1.66（1.33-2.07;p<0.001）。高表达预示预后较好的 circRNAs 与 OS 和 DFS 相关的总 HR（95%CI）分别为 0.54（0.45-0.66;p<0.001）和 0.58（0.43-0.78;p<0.001）。两组五个 circRNAs 预测的 HR 值更高（circ_0009910、hsa_circ_0000467、hsa_circ_0065149、hsa_circ_0081143 和 circDLST；以及 circSMARCA5、circLMTK2、hsa_circ_0001017、hsa_circ_0061276 和 circ-KIAA1244）。OS 的荟萃分析结果分别为 2.63（2.08-3.33;p<0.001）和 0.39（0.27-0.59;p<0.001）。这两组失调的 circRNAs 可以被认为是更适合胃癌患者的潜在预后肿瘤生物标志物，因为它们的 HR 值更大。
