Department of Cardiology, Faculty of Medicine, 37503Ataturk University, Erzurum, Turkey.
Department of Orthopedics, Faculty of Medicine, 37503Ataturk University, Erzurum, Turkey.
Angiology. 2021 Mar;72(3):268-273. doi: 10.1177/0003319720965808. Epub 2020 Oct 14.
The monocyte/high density lipoprotein cholesterol ratio (MHR) reflects the proatherogenic and antiatherogenic balance, and a high ratio is associated with the severity of atherosclerosis. We measured the MHR of patients with critical limb ischemia (CLI) due to peripheral artery disease (PAD) requiring amputation. Patients diagnosed with PAD were divided into 2 groups; those who underwent an amputation due to CLI without any sign of infection and those treated with surgical or percutaneous revascularization or followed up medically. A healthy control group was also included. In patients diagnosed with PAD (n = 563), the MHR value was higher for the control group (n = 200), (12.4 ± 0.42 vs 11.5 ± 0.28, < .001). In the amputation group, the MHR was significantly higher for the group treated by other methods (15.7 ± 1.52 vs 12.8 ± 1.45, < .001). Possible confounding factors affecting the MHR value were determined by the univariate regression analysis, and the multiple regression analysis revealed that MHR was an independent predictor of amputation in patients with PAD ( < .001). This study suggests that the MHR may be the predictor of amputation risk in patients with PAD and CLI.
单核细胞/高密度脂蛋白胆固醇比值（MHR）反映了动脉粥样硬化的促动脉粥样硬化和抗动脉粥样硬化平衡，比值高与动脉粥样硬化的严重程度有关。我们测量了因外周动脉疾病（PAD）导致需要截肢的严重肢体缺血（CLI）患者的 MHR。将被诊断为 PAD 的患者分为两组；一组因 CLI 而截肢且无任何感染迹象，另一组接受手术或经皮血运重建治疗或接受药物治疗。还纳入了一个健康对照组。在被诊断为 PAD（n = 563）的患者中，对照组（n = 200）的 MHR 值较高（12.4 ± 0.42 比 11.5 ± 0.28， <.001）。在截肢组中，其他方法治疗的组 MHR 明显更高（15.7 ± 1.52 比 12.8 ± 1.45， <.001）。通过单变量回归分析确定了可能影响 MHR 值的混杂因素，多元回归分析表明 MHR 是 PAD 患者截肢的独立预测因素（ <.001）。这项研究表明，MHR 可能是 PAD 和 CLI 患者截肢风险的预测因子。
