Department of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Geriatric Medicine Center, Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Department of Endocrinology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Front Endocrinol (Lausanne). 2023 Feb 16;14:1100453. doi: 10.3389/fendo.2023.1100453. eCollection 2023.
Neutrophil/high-density lipoprotein (HDL) ratio (NHR), monocyte/HDL ratio (MHR), lymphocyte/HDL ratio (LHR), platelet/HDL ratio (PHR), systemic immune-inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) have been recently investigated as novel inflammatory markers. Herein, the correlation was investigated between these inflammatory biomarkers and peripheral arterial disease (PAD) in type 2 diabetes mellitus (T2DM) patients.
In this retrospective observational study, the hematological parameter data of 216 T2DM patients without PAD (T2DM-WPAD) and 218 T2DM patients with PAD (T2DM-PAD) at Fontaine stages II, III or IV stage had been collected. Differences in NHR, MHR, LHR, PHR, SII, SIRI, and AISI were analyzed, and receiver operating characteristic (ROC) curves were used to analyze the diagnostic potential of these parameters.
The levels of NHR, MHR, PHR, SII, SIRI and AISI in T2DM-PAD patients were significantly higher than in T2DM-WPAD patients ( < 0.001). They were correlated with disease severity. Further, multifactorial logistic regression analyses showed that higher NHR, MHR, PHR, SII, SIRI, and AISI might be independent risk factors for T2DM-PAD ( < 0.001). The areas under the curve (AUCs) of the NHR, MHR, PHR, SII, SIRI, and AISI for T2DM-PAD patients was 0.703, 0.685, 0.606, 0.648, 0.711, and 0.670, respectively. The AUC of the NHR and SIRI combined model was 0.733.
The levels of NHR, MHR, PHR, SII, SIRI, and AISI were higher in T2DM-PAD patients, and they were independently linked with its clinical severity. The combination model of NHR and SIRI was most valuable for predicting T2DM - PAD.
中性粒细胞/高密度脂蛋白（HDL）比值（NHR）、单核细胞/HDL 比值（MHR）、淋巴细胞/HDL 比值（LHR）、血小板/HDL 比值（PHR）、全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）和全身炎症综合指数（AISI）最近被研究为新型炎症标志物。在此，研究了这些炎症生物标志物与 2 型糖尿病（T2DM）患者外周动脉疾病（PAD）之间的相关性。
本回顾性观察性研究收集了 216 例无 PAD（T2DM-WPAD）和 218 例 PAD（T2DM-PAD）的 T2DM 患者的血液学参数数据，这些患者的 Fontaine 分期为 II、III 或 IV 期。分析了 NHR、MHR、LHR、PHR、SII、SIRI 和 AISI 的差异，并使用受试者工作特征（ROC）曲线分析了这些参数的诊断潜力。
T2DM-PAD 患者的 NHR、MHR、PHR、SII、SIRI 和 AISI 水平明显高于 T2DM-WPAD 患者（<0.001）。它们与疾病严重程度相关。此外，多因素逻辑回归分析显示，较高的 NHR、MHR、PHR、SII、SIRI 和 AISI 可能是 T2DM-PAD 的独立危险因素（<0.001）。NHR、MHR、PHR、SII、SIRI 和 AISI 对 T2DM-PAD 患者的曲线下面积（AUC）分别为 0.703、0.685、0.606、0.648、0.711 和 0.670，NHR 和 SIRI 联合模型的 AUC 为 0.733。
T2DM-PAD 患者的 NHR、MHR、PHR、SII、SIRI 和 AISI 水平较高，且与临床严重程度独立相关。NHR 和 SIRI 联合模型对预测 T2DM-PAD 最有价值。
