Wang Bei, Li Liuyi, Feng Shuyan, Yu Lin, Feng Shuman
Department of Neuroelectrophysiology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, 7 Weiwu Street, Zhengzhou, 450003, China.
Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
BMC Neurol. 2025 Jul 31;25(1):315. doi: 10.1186/s12883-025-04310-5.
Migraine is closely related to sleep disorders. Vitamin D is known to regulate sleep, cell proliferation and differentiation. The aim of our study was to measure the predictive value of vitamin D for sleep disorders in paediatric migraine. We hypothesized that vitamin D would be apredictor of sleep disorders in paediatric migraine.
We conducted an analysis of serum vitamin D levels in 150 paediatric migraine. The Pittsburgh Sleep Quality Index (PSQI) was used as a measure of sleep quality. Based on the PSQI scores, the subjects were divided into normal sleep group and sleep disorder group. Correlation analysis and regression analysis were employed to explore the potential etiology of sleep disturbances in paediatric migraine.
There was significant difference in the prevalence of sleep disorders between paediatric migraine and the control group (Odds ratio [OR] = 4.91,95% confidence interval [CI] = 3.25-7.40, P = 0.001). Additionally, the regression analysis demonstrated that vitamin D could serve as a predictive factor for sleep disorders in paediatric migraine (OR = 0.008, 95%CI: 0.023-0.225, P = 0.004). The receiver operating characteristic (ROC) analysis revealed an area under the curve (AUC) of 0.957 (95% CI 0.925-0.988), with a cutoff value of 15.84 ng/ml, a sensitivity of 87.5%, and a specificity of 93.7% for serum vitamin D.
Our study confirms the association between sleep disorder and vitamin D levels in paediatric migraine. The use of vitamin D supplementation as a treatment strategy for sleep disturbances in paediatric migraine needs further investigation.
偏头痛与睡眠障碍密切相关。已知维生素D可调节睡眠、细胞增殖和分化。我们研究的目的是测量维生素D对小儿偏头痛睡眠障碍的预测价值。我们假设维生素D将是小儿偏头痛睡眠障碍的一个预测指标。
我们对150例小儿偏头痛患者的血清维生素D水平进行了分析。匹兹堡睡眠质量指数（PSQI）被用作睡眠质量的衡量指标。根据PSQI评分，将受试者分为正常睡眠组和睡眠障碍组。采用相关性分析和回归分析来探讨小儿偏头痛睡眠障碍的潜在病因。
小儿偏头痛组与对照组的睡眠障碍患病率存在显著差异（优势比[OR]=4.91，95%置信区间[CI]=3.25-7.40，P=0.001）。此外，回归分析表明维生素D可作为小儿偏头痛睡眠障碍的预测因素（OR=0.008，95%CI：0.023-0.225，P=0.004）。受试者工作特征（ROC）分析显示曲线下面积（AUC）为0.957（95%CI 0.925-0.988），血清维生素D的截断值为15.84 ng/ml，敏感性为87.5%，特异性为93.7%。
我们的研究证实了小儿偏头痛睡眠障碍与维生素D水平之间的关联。将补充维生素D作为小儿偏头痛睡眠障碍的治疗策略需要进一步研究。
