电化学疗法治疗皮肤黑色素瘤转移和罕见非黑色素瘤皮肤癌的疗效。
Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer.
机构信息
Department of Plastic and Reconstructive Surgery, Melanoma and Skin Cancer Unit, Regional Melanoma Referral Center, S.M. Annunziata Hospital, Florence, Italy.
Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
出版信息
Anticancer Res. 2020 Nov;40(11):6485-6492. doi: 10.21873/anticanres.14670.
BACKGROUND
We aimed to verify the clinical efficacy and safety of the electrochemotherapy in melanoma metastases and in cases of rare non-melanoma tumors that were difficult to treat for the specific anatomical site or for patient comorbidities.
PATIENTS AND METHODS
We treated 68 patients (699 cutaneous nodules), 44 patients with metastatic melanomas and 24 patients with non-melanoma tumors, at the Melanoma & Skin Cancer Unit, Florence, Italy.
RESULTS
We obtained an objective response of 89.7% (88.6% in melanomas and 91.7% in non-melanoma tumors), complete response 54.4% and partial response 35.3%.
CONCLUSION
This study showed that electrochemotherapy is effective in the treatment of melanoma metastases and in rare types of non-melanoma tumors. In particular, we successfully treated rare tumors as angiosarcoma, pleomorphic sarcoma, myxofibrosarcoma, sarcoma di Kaposi, porocarcinoma, sebaceous carcinoma, Merkel cell carcinoma, malignant blue nevus, undifferentiated epitheliomorphic cell neoplasia and metastases from thyroid carcinoma. No serious adverse events were observed.
背景
我们旨在验证电化学疗法在治疗黑色素瘤转移和罕见的非黑色素瘤肿瘤方面的临床疗效和安全性，这些肿瘤由于特定的解剖部位或患者合并症而难以治疗。
患者和方法
我们在意大利佛罗伦萨的黑色素瘤和皮肤癌科治疗了 68 名患者（699 个皮肤结节），其中 44 名患者患有转移性黑色素瘤，24 名患者患有非黑色素瘤肿瘤。
结果
我们获得了 89.7%的客观缓解率（黑色素瘤为 88.6%，非黑色素瘤肿瘤为 91.7%），完全缓解率为 54.4%，部分缓解率为 35.3%。
结论
这项研究表明，电化学疗法在治疗黑色素瘤转移和罕见类型的非黑色素瘤肿瘤方面是有效的。特别是，我们成功治疗了罕见的肿瘤，如血管肉瘤、多形性肉瘤、黏液纤维肉瘤、卡波西肉瘤、粉刺癌、皮脂癌、 Merkel 细胞癌、恶性蓝痣、未分化上皮样细胞肿瘤和甲状腺癌转移。未观察到严重的不良事件。
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