Patel Aditya S, Patel Shraddha A, Fulzele Puneet R, Mohod Swapnil C, Chandak Manoj, Patel Satyawan S
Department of Conservative Dentistry, Jazaan College of Dentistry, Jazaan University, Kingdom of Saudi Arabia.
Department of Oral Diagnosis and Radiology, Sharad Pawar Dental College, DMIMS DU, Sawangi meghe, Wardha, India.
Contemp Clin Dent. 2020 Apr-Jun;11(2):121-125. doi: 10.4103/ccd.ccd_128_19. Epub 2020 Aug 7.
Most of the currently used medications for the treatment of oral ulcers focus primarily on providing symptomatic relief and preventing secondary infections. Not much attention has been paid in the past on agents that can promote healing of these lesions. In the current study, we have tested and compared the efficacy of such wound healing promoting agents i.e. Propolis (product obtained from Bees) and a newly developed herbal ointment (containing extracts of (Neem), L.(Linseed) oil, and resin of Shorea robusta) in experimental rabbits.
Traumatic oral ulcers were inflicted in experimental rabbits (New Zealand white) with the help of a punch biopsy instrument. The animals were then divided into three groups each group consisted of 12 animals ( = 12), Group I was the untreated control group and Group II was topically treated with nonalcohol extract of propolis and Group III was treated with newly developed herbal ointment. Histological healing scores of the ulcers were evaluated on day 7 and day 14. Data were statistically analyzed using descriptive and inferential statistic methods.
In Group III treated with newly developed herbal ointment, significantly higher healing scores, in comparison to the untreated control group (Group I) and propolis (Group II) was observed on day 7 and 14. Improved healing scores in prapolis-treated group were observed than the untreated control group. However, the difference was not statistically significant on both day 7 and day 14.
With the newly developed herbal ointment, superior healing of traumatic oral ulcers was observed.
目前用于治疗口腔溃疡的大多数药物主要侧重于缓解症状和预防继发感染。过去对能够促进这些溃疡愈合的药物关注较少。在本研究中，我们在实验兔中测试并比较了这类促进伤口愈合药物的疗效，即蜂胶（从蜜蜂获得的产品）和一种新开发的草药软膏（含有印楝提取物、亚麻籽油和娑罗双树树脂）。
借助打孔活检器械在实验兔（新西兰白兔）身上造成创伤性口腔溃疡。然后将动物分为三组，每组12只（n = 12），第一组为未治疗的对照组，第二组用蜂胶非酒精提取物进行局部治疗，第三组用新开发的草药软膏治疗。在第7天和第14天评估溃疡的组织学愈合评分。使用描述性和推断性统计方法对数据进行统计学分析。
在第7天和第14天，与未治疗的对照组（第一组）和蜂胶组（第二组）相比，用新开发的草药软膏治疗的第三组观察到显著更高的愈合评分。蜂胶治疗组的愈合评分高于未治疗的对照组。然而，在第7天和第l4天，差异均无统计学意义。
使用新开发的草药软膏观察到创伤性口腔溃疡的愈合情况更佳。
