Naseri Saeed, Golpich Mojtaba, Roshancheshm Tohid, Joobeni Mohammad Ghadimi, Khodayari Moein, Noori Salar, Zahed Seyyed Asghar, Razzaghi Sara, Shirzad Mohammad, Salavat Farhad Saber, Dakhilpour Seyede Simin
Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
Department of Biology, Faculty of Science, University of Isfahan, Hezarjerib Street, Isfahan, Iran.
Burns. 2021 Sep;47(6):1442-1450. doi: 10.1016/j.burns.2020.12.009. Epub 2020 Dec 11.
The treatment of skin burns is one of the most important challenge in medical science. The aim of this study is evaluation of the efficacy of Artaderm herbal ointment containing the Henna (Lawsonia inermis) extract, Linseed (Linum usitatissimum) oil, and Honey Wax on wound healing in the rat with second-degree burn wounds. The Artaderm ointment had an effective role in controlling burn wound infections due to its antimicrobial and anti-inflammatory properties. In this study, 64 male Wistar rats were randomly divided into 8 groups (n = 8). Four groups received Artaderm, 1% Silver Sulfadiazine (SSD 1%), Cod Liver Oil and Fundermol (Alpha) ointments which used in common practices for burn injuries. Another three groups received Henna, Linseed, and Honey Wax alone and a control group that just underwent a second-degree burn injury without any treatments. A second-degree burn was formed on the back of each rat and dressed daily with one of the agents. Burn wounds were macroscopically and microscopically evaluated on the 7th, 14th, and 21st day after burn induction. Rats treated with the Artaderm ointment had significantly faster wound contraction as well as shorter healing time than the rest groups. No scar was observed in rats treated with the Artaderm ointment on the 21st day, while this level of improvement was not observed in other groups at the same time. More than 90% of wounds were healed after on the 14th day in rats treated with Artaderm (94.10 ± 0.18) and Alpha (92.05 ± 0.23) ointments. According to these findings, it can be concluded that Artaderm herbal ointment can be used as a proper alternative for healing of wounds in second-degree burns.
皮肤烧伤的治疗是医学领域最重要的挑战之一。本研究的目的是评估含有指甲花（散沫花）提取物、亚麻籽油和蜜蜡的Artaderm草药软膏对大鼠二度烧伤创面愈合的疗效。Artaderm软膏因其抗菌和抗炎特性，在控制烧伤创面感染方面发挥了有效作用。在本研究中，64只雄性Wistar大鼠被随机分为8组（每组n = 8）。四组分别接受Artaderm、1%磺胺嘧啶银（SSD 1%）、鱼肝油和Fundermol（Alpha）软膏，这些都是烧伤治疗中的常用药物。另外三组分别单独接受指甲花、亚麻籽和蜜蜡治疗，还有一组作为对照组，仅接受二度烧伤，不进行任何治疗。在每只大鼠背部造成二度烧伤，并每天用其中一种药物进行包扎。在烧伤诱导后的第7天、14天和21天，对烧伤创面进行宏观和微观评估。与其他组相比，接受Artaderm软膏治疗的大鼠创面收缩明显更快，愈合时间更短。在第21天，接受Artaderm软膏治疗的大鼠未观察到瘢痕形成，而其他组在同一时间未达到这种改善程度。在接受Artaderm（94.10 ± 0.18）和Alpha（92.05 ± 0.23）软膏治疗的大鼠中，超过90%的创面在第14天愈合。根据这些发现，可以得出结论，Artaderm草药软膏可作为二度烧伤创面愈合的合适替代药物。
