Arthisri Anandhi Sekar, Sathiyamoorthy Asokan, Meenakshi Bhagavatham, Chandran Chitraa R
Department of Oral Medicine and Radiology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
Department of Oral Medicine and Radiology, Tagore Dental College and Hospital, Chennai, Tamil Nadu, India.
Contemp Clin Dent. 2020 Apr-Jun;11(2):131-135. doi: 10.4103/ccd.ccd_336_20. Epub 2020 Aug 7.
Lack of noninvasive and economically feasible laboratory investigations in the early detection of cancer is a set-back in the prognosis of oral cancer (OC) patients.
The aim of the study was to evaluate the ratio of sialic acid to fucose in salivary samples of OC and oral potentially malignant disorder (OPMD) patients.
A total of 60 participants were selected and divided into three groups based on clinical and histopathological diagnosis: OC patients ( = 20), OPMD patients ( = 20), and healthy patients ( = 20). Unstimulated whole saliva of 1.5 ml was collected from the selected individuals for evaluating the salivary levels of sialic acid and fucose using the biochemical assay.
The difference in mean salivary sialic acid and fucose among the study groups was statistically significant ( = 0.001); one-way analysis of variance. The mean sialic acid to fucose ratio in the control group, OPMD group, and OC group were 0.34 mg/dl, 0.88 mg/dl, and 0.89 mg/dl, respectively. OC patients had significant elevation in the levels of salivary sialic acid, fucose, and their ratios ( = 0.001, = 0.001, = 0.003, respectivel; Tukey's test.
The ratio of salivary sialic acid to fucose is a predictable tumor marker for the diagnosis of OC. Further investigations are required to evaluate the influence of OC grading on this diagnostic marker.
在癌症早期检测中缺乏无创且经济可行的实验室检查方法是口腔癌（OC）患者预后的一个障碍。
本研究的目的是评估OC患者和口腔潜在恶性疾病（OPMD）患者唾液样本中唾液酸与岩藻糖的比例。
共选取60名参与者，根据临床和组织病理学诊断分为三组：OC患者（n = 20）、OPMD患者（n = 20）和健康患者（n = 20）。从选定个体中收集1.5毫升未刺激的全唾液，使用生化检测方法评估唾液酸和岩藻糖的唾液水平。
研究组之间唾液酸和岩藻糖的平均水平差异具有统计学意义（P = 0.001）；单因素方差分析。对照组、OPMD组和OC组唾液酸与岩藻糖的平均比例分别为0.34毫克/分升、0.88毫克/分升和0.89毫克/分升。OC患者唾液酸、岩藻糖水平及其比例均显著升高（分别为P = 0.001、P = 0.001、P = 0.003；Tukey检验）。
唾液酸与岩藻糖的比例是诊断OC的一种可预测的肿瘤标志物。需要进一步研究以评估OC分级对该诊断标志物的影响。
