岩藻糖：口腔癌分级中的一种生物标志物。
Fucose: A biomarker in grading of oral cancer.
作者信息
Kumar Satish, Saxena Mona, Srinivas Kandakurtis, Singh Vinod Kumar
机构信息
Department of Oral Medicine, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India.
Department of Biochemistry, Career Institute of Medical Sciences and Hospital, Lucknow, Uttar Pradesh, India.
出版信息
Natl J Maxillofac Surg. 2015 Jul-Dec;6(2):176-9. doi: 10.4103/0975-5950.183869.
INTRODUCTION
Early diagnosis of cancer helps a great deal in the management of oral cancer patients. Number of proteinous markers have been employed for this purpose. Majority of them are not specific. Recently conjugated oligosaccharide with proteins and lipids have gained considerable importance in the present postgenomics and postproteomic period in the diagnostic and prognostics of cancer cases.
MATERIALS AND METHODS
In this study, serum fucose levels were estimated in 50 control cases and 75 cases of oral cancer by the method of Dische and Shettles as adopted by Winzler.
RESULTS
Serum fucose levels were found to be significantly higher in oral cancer cases (46.63 ± 5.29 mg/dl) as compared to the control cases (7.22 ± 0.26 mg/dl). The stepwise elevated serum fucose levels were found to be correlated with the histopathological grading of oral cancer.
CONCLUSIONS
Estimation of such fucose conjugated proteins is suggestive to be good biomarkers in the diagnosis of oral cancer cases as well as in assessing the prognosis of such cases.
引言
癌症的早期诊断对口腔癌患者的治疗有很大帮助。为此已采用了多种蛋白质标志物。其中大多数并不具有特异性。最近，在当前的后基因组学和后蛋白质组学时代，蛋白质和脂质结合的低聚糖在癌症病例的诊断和预后方面变得相当重要。
材料与方法
在本研究中，采用温兹勒所采用的迪谢和谢特尔斯方法，对50例对照病例和75例口腔癌病例的血清岩藻糖水平进行了测定。
结果
发现口腔癌病例的血清岩藻糖水平（46.63±5.29毫克/分升）显著高于对照病例（7.22±0.26毫克/分升）。血清岩藻糖水平的逐步升高与口腔癌的组织病理学分级相关。
结论
对这种岩藻糖结合蛋白的测定表明，它有望成为口腔癌病例诊断以及此类病例预后评估的良好生物标志物。
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