Department of Neurosurgery, Medical University of Lublin, Poland.
Department of Neurology, Medical University of Lublin, Poland.
Dis Markers. 2020 Oct 13;2020:1318930. doi: 10.1155/2020/1318930. eCollection 2020.
We investigated the influence of pain decrease after lumbar microdiscectomy on the interferon gamma (IFN-) serum level in patients with lumbar disc herniations. The study challenges the mechanism of sciatica pain and the role of IFN- in radicular pain development. . We performed clinical and immunoenzymatic assessment in a group of 27 patients with lumbar radicular pain due to disc herniations before and 3 months after surgery. Clinical status was assessed with the use of the Numeric Rating Scale (NRS), the Pain Rating Index and Pain Intensity Index of McGill Pain Questionnaire (SF-MPQ), the Oswestry Disability Index (ODI), and Beck Depression Inventory (BDI). The plasma concentrations of IFN- were ascertained by an immunoenzymatic method.
We observe significant correlations between the results of the pain in the back region assessment NRS back scale after the surgery with the level of IFN- before the procedure ( = 0.528; = 0.008) and after the procedure ( = 0.455; = 0.025). These are moderate and positive correlations-the decrease in pain is correlated with the lower IFN- level. Additionally, there are significant correlations between the results of the PRI scale and the IFN- level. The PRI score before surgery correlates positively with IFN- after surgery ( = 0.462; = 0.023), and the PRI score after surgery correlates positively with IFN before surgery ( = 0.529; = 0.005) and after surgery ( = 0.549; = 0.003). All correlations are moderate in severity-severe pain before surgery correlates with a higher level of IFN- after surgery and also higher IFN- before surgery. There were significant differences in the IFN- level before ( = -2.733; = 0.006) and after ( = -2.391; = 0.017) surgery in the groups of patients with and without nerve compression. In the group of patients with nerve compression, the level of IFN- before and after surgery was lower.
Less pain ratio after operation correlates with the level of IFN-. In the group of patients without significant nerve compression confirmed by MRI scans, the level of IFN- before and after surgery was higher than that in the group with nerve root compression.
我们研究了腰椎间盘突出症患者腰椎间盘切除术后疼痛减轻对干扰素 γ（IFN-）血清水平的影响。该研究对坐骨神经痛的发病机制和 IFN-在神经根痛发展中的作用提出了挑战。我们在一组因椎间盘突出导致神经根痛的 27 例患者中进行了临床和免疫酶评估，在手术前和手术后 3 个月进行。临床状态采用数字评分量表（NRS）、麦吉尔疼痛问卷的疼痛评分指数和疼痛强度指数（SF-MPQ）、Oswestry 残疾指数（ODI）和贝克抑郁量表（BDI）进行评估。通过免疫酶法测定 IFN-的血浆浓度。
我们观察到术后背部 NRS 评分与术前（ = 0.528； = 0.008）和术后（ = 0.455； = 0.025）IFN-水平之间存在显著相关性。这些是中度和正相关——疼痛的减轻与 IFN-水平的降低相关。此外，PRI 量表的结果与 IFN-水平之间存在显著相关性。术前 PRI 评分与术后 IFN-呈正相关（ = 0.462； = 0.023），术后 PRI 评分与术前 IFN-呈正相关（ = 0.529； = 0.005）和术后（ = 0.549； = 0.003）。所有相关性均为中度强度——术前严重疼痛与术后 IFN-水平较高相关，也与术前 IFN-水平较高相关。有神经压迫和无神经压迫的患者 IFN-水平在术前（ = -2.733； = 0.006）和术后（ = -2.391； = 0.017）均有显著差异。在有神经压迫的患者组中，手术前后 IFN-的水平较低。
术后疼痛减轻比例与 IFN-水平相关。在 MRI 扫描未证实有明显神经压迫的患者组中，手术前后 IFN-水平高于有神经根压迫的患者组。
