血清微小RNA可在多民族人群中识别早期结直肠癌。
Serum micro-RNA Identifies Early Stage Colorectal Cancer in a Multi-Ethnic Population.
作者信息
Shiosaki Jessica, Tiirikainen Maarit, Peplowska Karolina, Shaeffer David, Machida Michio, Sakamoto Kazuhiro, Takahashi Makoto, Kojima Kuniaki, Machi Junji, Bryant-Greenwood Peter, Kuwada Scott K
机构信息
John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, MEB, Honolulu, Hawaii, United States.
University of Hawaii Cancer Center, 01 Ilalo Street, Honolulu, Hawaii, United States.
出版信息
Asian Pac J Cancer Prev. 2020 Oct 1;21(10):3019-3026. doi: 10.31557/APJCP.2020.21.10.3019.
OBJECTIVE
Certain microRNAs (miR) have been previously described to be dysregulated in cancers and can be detected in blood samples. Studies examining the utility of miRs for colon cancer screening have primarily been performed in ethnically homogeneous groups of patients, thus the performance of miRs in multiethnic populations is unknown.
METHODS
Four miRs were selected that were shown to be aberrantly expressed in the blood or stool of patients with colorectal cancer (CRC) of various ethnicities. In this study, the ability of these miRs to discern early stage CRC was determined in a previously untested multiethnic population of 73 CRC cases and 18 controls.
RESULTS
The ratios of non-vesicular to extracellular vesicular levels of miR's -21, -29a, and -92a were statistically and quantitatively related to CRC stage compared to controls.
CONCLUSION
Serum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population.
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目的
先前已有研究表明某些微小RNA（miR）在癌症中表达失调，且可在血液样本中检测到。关于miR用于结肠癌筛查效用的研究主要在种族单一的患者群体中进行，因此miR在多民族人群中的表现尚不清楚。
方法
选择了四种miR，它们在不同种族的结直肠癌（CRC）患者的血液或粪便中显示出异常表达。在本研究中，在一个由73例CRC病例和18例对照组成的此前未测试过的多民族人群中，确定了这些miR辨别早期CRC的能力。
结果
与对照组相比，miR-21、-29a和-92a的非囊泡与细胞外囊泡水平之比在统计学和定量上与CRC分期相关。
结论
在一个多民族且此前未测试过的人群中，miR-21、miR-29a和miR-92a的血清水平能够显著检测出早期CRC。
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