Stowers Institute for Medical Research, Kansas City, MO 64110, United States; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, United States.
Curr Opin Struct Biol. 2021 Feb;66:22-31. doi: 10.1016/j.sbi.2020.09.008. Epub 2020 Oct 25.
The fungal kingdom is large and diverse, representing extremes of ecology, life cycles and morphology. At a cellular level, the diversity among fungi is particularly apparent at the spindle pole body (SPB). This nuclear envelope embedded structure, which is essential for microtubule nucleation, shows dramatically different morphologies between different fungi. However, despite phenotypic diversity, many SPB components are conserved, suggesting commonalities in structure, function and duplication. Here, I review the organization of the most well-studied SPBs and describe how advances in genomics, genetics and cell biology have accelerated knowledge of SPB architecture in other fungi, providing insights into microtubule nucleation and other processes conserved across eukaryotes.
真菌界种类繁多，生态、生命周期和形态各异。在细胞水平上，真菌之间的多样性在纺锤体极体（SPB）中表现得尤为明显。这个核被膜嵌入的结构对于微管的核形成是必不可少的，在不同的真菌之间表现出截然不同的形态。然而，尽管表型多样，许多 SPB 成分是保守的，这表明在结构、功能和复制方面存在共性。在这里，我回顾了研究最充分的 SPB 的组织，并描述了基因组学、遗传学和细胞生物学的进展如何加速了其他真菌中 SPB 结构的知识，为微管核形成和其他在真核生物中保守的过程提供了新的见解。
