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儿童和青少年高血压的新诊断标准:机遇与挑战

New Diagnostic Criteria for Hypertension in Children and Adolescents: Lights and Shadows.

作者信息

Di Bonito Procolo, Di Sessa Anna

机构信息

Department of Internal Medicine, "S. Maria delle Grazie" Pozzuoli Hospital, 80078 Naples, Italy.

Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

出版信息

Children (Basel). 2020 Oct 24;7(11):196. doi: 10.3390/children7110196.

Abstract

Pediatric hypertension (HTN) represents a challenging disease with a major cardiometabolic risk (CMR) burden from childhood to adulthood. In fact, it has been linked to cardiac and vascular damage even at pediatric age and recognized as an independent risk factor for HTN in adulthood. Therefore, HTN in children has gained remarkable scientific interest during the past decades. However, the availability of different diagnostic classifications complicates HTN definition. The Clinical Practice Guidelines released in 2017 updated the diagnostic criteria, by highlighting some important issues with clinical implications. Lowering the new cut-offs proposed by the CPG, as compared with those proposed by IV Report criteria, will increase the number of young people at risk of hypertension. However, evidence suggests that the CPG cutoff-points in further identifying subjects with an altered CMR profile. Currently, some issues are still debated such as the adoption of a fixed cut-off of BP ≥ 130/80 mmHg for children aged ≥ 13 years, or the adoption of criteria for cardiac damage derived from adults. Given the CMR burden of pediatric HTN, a better and early identification of children at higher HTN risk is strictly recommended in order to improve HTN management to reduce the cardiovascular risk in these youths.

摘要

小儿高血压(HTN)是一种具有挑战性的疾病,从儿童期到成年期都伴有重大的心脏代谢风险(CMR)负担。事实上,即使在儿童时期,它也与心脏和血管损伤有关,并被认为是成年期高血压的独立危险因素。因此,在过去几十年中,儿童高血压引起了科学界的极大兴趣。然而,不同诊断分类的存在使高血压的定义变得复杂。2017年发布的临床实践指南更新了诊断标准,强调了一些具有临床意义的重要问题。与IV报告标准提出的临界值相比,降低CPG提出的新临界值将增加有高血压风险的年轻人数量。然而,有证据表明,CPG临界值在进一步识别心脏代谢状况改变的受试者方面具有优势。目前,一些问题仍在争论中,例如对于13岁及以上儿童采用血压≥130/80 mmHg的固定临界值,或者采用源自成人的心脏损伤标准。鉴于小儿高血压的CMR负担,强烈建议更好地早期识别高血压风险较高的儿童,以改善高血压管理,降低这些年轻人的心血管风险。

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