Institute of Physiology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.
Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, 814 39 Bratislava, Slovakia.
Int J Mol Sci. 2020 Oct 26;21(21):7958. doi: 10.3390/ijms21217958.
The development and progression of cancer depends on both tumor micro- and macroenvironments. In addition, psychosocial and spiritual "environments" might also affect cancer. It has been found that the nervous system, via neural and humoral pathways, significantly modulates processes related to cancer at the level of the tumor micro- and macroenvironments. The nervous system also mediates the effects of psychosocial and noetic factors on cancer. Importantly, data accumulated in the last two decades have clearly shown that effects of the nervous system on cancer initiation, progression, and the development of metastases are mediated by the sympathoadrenal system mainly via β-adrenergic receptor signaling. Here, we provide a new complex view of the role of β-adrenergic receptor signaling within the tumor micro- and macroenvironments as well as in mediating the effects of the psychosocial and spiritual environments. In addition, we describe potential preventive and therapeutic implications.
癌症的发生和发展既取决于肿瘤微环境，也取决于肿瘤宏环境。此外，心理社会和精神“环境”也可能影响癌症。研究发现，神经系统通过神经和体液途径，显著调节肿瘤微环境和宏环境中与癌症相关的过程。神经系统还介导心理社会和认知因素对癌症的影响。重要的是，过去二十年积累的数据清楚地表明，神经系统对癌症发生、进展和转移发展的影响主要通过交感肾上腺系统通过β肾上腺素能受体信号传导来介导。在这里，我们提供了一个关于β肾上腺素能受体信号在肿瘤微环境和宏环境中的作用以及在介导心理社会和精神环境的影响的新的复杂观点。此外，我们还描述了潜在的预防和治疗意义。
