Eleanor M. Saffran Center for Cognitive Neuroscience, Temple University, Philadelphia, PA, USA.
Department of Communication Sciences and Disorders, Temple University, Philadelphia, PA, USA.
Neuropsychol Rehabil. 2022 May;32(4):560-578. doi: 10.1080/09602011.2020.1835676. Epub 2020 Oct 28.
The dynamic and unpredictable nature of expressive vocabulary dropout in progressive anomia presents a challenge for language intervention. We evaluated whether eye gaze patterns during naming could predict anomia for the same items in the near future. We tracked naming accuracy and gaze patterns as patients with semantic ( = 7) or logopenic ( = 2) variants of Primary Progressive Aphasia or amnestic Alzheimer's Disease ( = 1), named photographs of people and objects. Patients were tested three or more times spaced roughly evenly over an average duration of 19.1 months. Target words named accurately at baseline were retrospectively coded as either known (i.e., consistently named) or vulnerable (i.e., inaccurately or inconsistently named) based on naming accuracy over the study interval. We extracted gaze data corresponding to successful naming attempts and implemented logistic mixed effects models to determine whether common gaze measures could predict each word's naming status as known or vulnerable. More visual fixations and greater visual fixation dispersion predicted later anomia. These findings suggest that eye tracking may yield a biomarker of the robustness of particular target words to future expressive vocabulary dropout. We discuss the potential utility of this finding for optimizing treatment for progressive anomia.
在进行性命名障碍中，表达性词汇缺失的动态和不可预测性质给语言干预带来了挑战。我们评估了命名过程中的注视模式是否可以预测近期内相同项目的命名障碍。我们跟踪了语义性（ = 7）或流畅性语言障碍（ = 2）原发性进行性失语症或遗忘型阿尔茨海默病（ = 1）患者对人物和物体照片的命名准确性和注视模式。患者在平均 19.1 个月的时间内，大约均匀地间隔三次或更多次进行测试。根据研究期间的命名准确性，将基线时准确命名的目标词回顾性地编码为已知（即，一致命名）或易损（即，不准确或不一致命名）。我们提取了与成功命名尝试相对应的注视数据，并实施了逻辑混合效应模型，以确定常见的注视指标是否可以预测每个单词的命名状态是已知还是易损。更多的视觉注视和更大的视觉注视分散度预测了以后的命名障碍。这些发现表明，眼动追踪可能为特定目标词未来表达性词汇缺失的稳健性提供生物标志物。我们讨论了这一发现对优化进行性命名障碍治疗的潜在效用。
