Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Psychology, Cleveland State University Cleveland, OH, USA.
Brain Lang. 2022 Sep;232:105165. doi: 10.1016/j.bandl.2022.105165. Epub 2022 Jul 28.
Eye movement studies can uncover subtle aspects of language processing impairment in individuals with primary progressive aphasia (PPA), who may have difficulty understanding words. This study examined eye movement patterns on a word-object matching task in response to varying levels of word-knowledge in PPA.
Participants with semantic and non-semantic PPA completed an object-matching task, where a word was presented and participants then selected the corresponding pictured object from an array. Afterwards, participants defined words for trials to which they incorrectly pointed. Linear mixed-effects analyses examined fixation differences on targets and related and unrelated foils.
On incorrectly-pointed trials, participants demonstrated greater fixation duration on related foils, demonstrating intra-category blurring. For words that could not be defined, there was similar fixation duration on related and unrelated foils, demonstrating inter-category semantic blurring.
This study demonstrated that fixation patterns reflect varying levels of word knowledge in PPA.
眼动研究可以揭示原发性进行性失语症 (PPA) 患者语言处理障碍的细微方面，这些患者可能在理解单词方面有困难。本研究通过词-物匹配任务，考察了 PPA 患者在不同单词知识水平下的眼动模式。
患有语义性和非语义性 PPA 的参与者完成了一项物体匹配任务，任务中呈现一个单词，然后参与者从一系列图片中选择对应的图片。之后，参与者对他们指错的单词进行定义。线性混合效应分析考察了目标和相关及不相关干扰项上的注视差异。
在指错的试验中，参与者在相关干扰项上的注视时间延长，表现出类别内模糊。对于无法定义的单词，相关和不相关干扰项上的注视时间相似，表现出类别间语义模糊。
本研究表明，注视模式反映了 PPA 患者不同水平的单词知识。
