产妇、配偶及新生儿在分娩时的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）抗体。
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns.
机构信息
Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Methods and Analysis, Statistics Denmark, Copenhagen, the Recurrent Pregnancy Loss Unit, the Capital Region, Rigshospitalet, Copenhagen University Hospital, Copenhagen, the Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, the Department of Obstetrics and Gynaecology, the Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, the Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, the DNRF Center for Chromosome Stability (CCS), Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, the Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, and the Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
出版信息
Obstet Gynecol. 2021 Jan 1;137(1):49-55. doi: 10.1097/AOG.0000000000004199.
OBJECTIVE
To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and their newborns and the association of such antibodies with obstetric and neonatal outcomes.
METHODS
From April 4 to July 3, 2020, in a single university hospital in Denmark, all parturient women and their partners were invited to participate in the study, along with their newborns. Participating women and partners had a pharyngeal swab and a blood sample taken at admission; immediately after delivery, a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by polymerase chain reaction, and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history and obstetric and neonatal information were available.
RESULTS
A total of 1,313 parturient women (72.5.% of all women admitted for delivery at the hospital in the study period), 1,188 partners, and 1,206 newborns participated in the study. The adjusted serologic prevalence was 2.6% in women and 3.5% in partners. Seventeen newborns had SARS-CoV-2 immunoglobulin G (IgG) antibodies, and none had immunoglobulin M antibodies. No associations between SARS-CoV-2 antibodies and obstetric or neonatal complications were found (eg, preterm birth, preeclampsia, cesarean delivery, Apgar score, low birth weight, umbilical arterial pH, need for continuous positive airway pressure, or neonatal admission), but statistical power to detect such differences was low. Full serologic data from 1,051 families showed an absolute risk of maternal infection of 39% if the partner had antibodies.
CONCLUSION
We found no association between SARS-CoV-2 infection and obstetric or neonatal complications. Sixty-seven percent of newborns delivered by mothers with antibodies had SARS-CoV-2 IgG antibodies. A limitation of our study is that we lacked statistical power to detect small but potentially meaningful differences between those with and without evidence of infection.
目的
调查产妇、其伴侣和新生儿中严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）抗体的频率，以及这些抗体与产科和新生儿结局的关系。
方法
2020 年 4 月 4 日至 7 月 3 日，在丹麦的一家大学医院，邀请所有产妇及其伴侣以及新生儿参加研究。参与的女性及其伴侣在入院时接受咽拭子和血液样本采集；新生儿出生后立即从脐静脉抽取血液样本。通过聚合酶链反应分析拭子中的 SARS-CoV-2 RNA，分析血液样本中的 SARS-CoV-2 抗体。有完整的病史和产科及新生儿信息。
结果
共有 1313 名产妇（研究期间在该医院分娩的所有女性的 72.5%）、1188 名伴侣和 1206 名新生儿参加了研究。调整后的血清学流行率为女性 2.6%，伴侣 3.5%。17 名新生儿有 SARS-CoV-2 免疫球蛋白 G（IgG）抗体，均无免疫球蛋白 M 抗体。未发现 SARS-CoV-2 抗体与产科或新生儿并发症之间存在关联（例如早产、子痫前期、剖宫产、阿普加评分、低出生体重、脐动脉 pH 值、需要持续气道正压通气或新生儿入院），但检测这种差异的统计能力较低。1051 个家庭的完整血清学数据显示，如果伴侣有抗体，母亲感染的绝对风险为 39%。
结论
我们未发现 SARS-CoV-2 感染与产科或新生儿并发症之间存在关联。67%的由有抗体的母亲分娩的新生儿有 SARS-CoV-2 IgG 抗体。本研究的局限性在于我们缺乏检测有感染证据和无感染证据的个体之间微小但可能有意义差异的统计能力。
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