Rapetti-Mauss Raphael, Berenguier Camille, Allegrini Benoit, Soriani Olivier
Inserm, CNRS, iBV, Université Côte d'Azur, Nice, France.
Front Pharmacol. 2020 Sep 29;11:525020. doi: 10.3389/fphar.2020.525020. eCollection 2020.
Increasing evidence point out the important roles of ion channels in the physiopathology of cancers, so that these proteins are now considered as potential new therapeutic targets and biomarkers in this disease. Indeed, ion channels have been largely described to participate in many hallmarks of cancers such as migration, invasion, proliferation, angiogenesis, and resistance to apoptosis. At the molecular level, the development of cancers is characterised by alterations in transduction pathways that control cell behaviors. However, the interactions between ion channels and cancer-related signaling pathways are poorly understood so far. Nevertheless, a limited number of reports have recently addressed this important issue, especially regarding the interaction between ion channels and one of the main driving forces for cancer development: the Wnt/β-catenin signaling pathway. In this review, we propose to explore and discuss the current knowledge regarding the interplay between ion channels and the Wnt/β-catenin signaling pathway in cancers.
越来越多的证据表明离子通道在癌症的生理病理学中发挥着重要作用，因此这些蛋白质现在被视为该疾病潜在的新治疗靶点和生物标志物。事实上，离子通道在很大程度上被描述为参与癌症的许多特征，如迁移、侵袭、增殖、血管生成和抗凋亡。在分子水平上，癌症的发展以控制细胞行为的转导途径改变为特征。然而，到目前为止，人们对离子通道与癌症相关信号通路之间的相互作用了解甚少。尽管如此，最近有少数报告探讨了这个重要问题，特别是关于离子通道与癌症发展的主要驱动力之一：Wnt/β-连环蛋白信号通路之间的相互作用。在这篇综述中，我们建议探索和讨论目前关于癌症中离子通道与Wnt/β-连环蛋白信号通路之间相互作用的知识。
