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The Mitigating Effect of Phentermine and Topiramate on Weight Regain After Roux-en-Y Gastric Bypass Surgery. phentermine 和托吡酯对 Roux-en-Y 胃旁路手术后体重反弹的缓解作用。
Obesity (Silver Spring). 2020 Jun;28(6):1023-1030. doi: 10.1002/oby.22786.
2
Metabolic adaptation is not a major barrier to weight-loss maintenance.代谢适应不是减肥维持的主要障碍。
Am J Clin Nutr. 2020 Sep 1;112(3):558-565. doi: 10.1093/ajcn/nqaa086.
3
Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists.肥胖与代谢外科医师协会、美国临床内分泌医师协会/美国内分泌学会、美国代谢与减重外科学会、美国肥胖医学协会和美国麻醉医师学会共同发布的《肥胖患者减重手术围手术期营养、代谢和非手术支持临床实践指南 2019 更新版》
Surg Obes Relat Dis. 2020 Feb;16(2):175-247. doi: 10.1016/j.soard.2019.10.025. Epub 2019 Oct 31.
4
Towards Optimized Care After Bariatric Surgery by Physical Activity and Exercise Intervention: a Review.通过身体活动和运动干预实现减重手术后的优化护理:综述。
Obes Surg. 2020 Mar;30(3):1118-1125. doi: 10.1007/s11695-020-04390-x.
5
CLINICAL PRACTICE GUIDELINES FOR THE PERIOPERATIVE NUTRITION, METABOLIC, AND NONSURGICAL SUPPORT OF PATIENTS UNDERGOING BARIATRIC PROCEDURES - 2019 UPDATE: COSPONSORED BY AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY, THE OBESITY SOCIETY, AMERICAN SOCIETY FOR METABOLIC & BARIATRIC SURGERY, OBESITY MEDICINE ASSOCIATION, AND AMERICAN SOCIETY OF ANESTHESIOLOGISTS - .肥胖患者减重手术围手术期营养、代谢和非手术支持临床实践指南-2019 年更新:美国临床内分泌医师协会/美国内分泌学会、肥胖协会、美国代谢与减重外科学会、肥胖医学协会和美国麻醉师协会共同赞助
Endocr Pract. 2019 Dec;25(12):1346-1359. doi: 10.4158/GL-2019-0406. Epub 2019 Nov 4.
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Definitions of Long-Term Weight Regain and Their Associations with Clinical Outcomes.长期体重复增的定义及其与临床结局的关联。
Obes Surg. 2020 Feb;30(2):527-536. doi: 10.1007/s11695-019-04210-x.
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Liraglutide 3.0 mg for the management of insufficient weight loss or excessive weight regain post-bariatric surgery.利拉鲁肽3.0毫克用于治疗减肥手术后体重减轻不足或体重过度反弹。
Clin Obes. 2019 Aug;9(4):e12323. doi: 10.1111/cob.12323. Epub 2019 Jun 10.
8
Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial.代谢手术后持续性或复发性 2 型糖尿病患者的辅助利拉鲁肽治疗(GRAVITAS):一项随机、双盲、安慰剂对照试验。
Lancet Diabetes Endocrinol. 2019 Jul;7(7):549-559. doi: 10.1016/S2213-8587(19)30157-3. Epub 2019 Jun 4.
9
Systematic Review and Meta-analysis of the Change in Ghrelin Levels After Roux-en-Y Gastric Bypass.Roux-en-Y 胃旁路术后生长激素释放肽水平变化的系统评价和荟萃分析。
Obes Surg. 2019 Apr;29(4):1343-1351. doi: 10.1007/s11695-018-03686-3.
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Prevalence of Dumping Syndrome After Laparoscopic Sleeve Gastrectomy and Comparison with Laparoscopic Roux-en-Y Gastric Bypass.腹腔镜袖状胃切除术后倾倒综合征的发生率及与腹腔镜Roux-en-Y胃旁路术的比较。
Obes Surg. 2019 May;29(5):1506-1513. doi: 10.1007/s11695-018-03699-y.

患者处理:减重手术后体重反弹患者的处理。

Approach to the Patient: Management of the Post-Bariatric Surgery Patient With Weight Regain.

机构信息

Section of Endocrinology, Diabetes, Nutrition, and Weight Management, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.

Section of Minimally Invasive Surgery, Department of Surgery, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.

出版信息

J Clin Endocrinol Metab. 2021 Jan 1;106(1):251-263. doi: 10.1210/clinem/dgaa702.

DOI:10.1210/clinem/dgaa702
PMID:33119080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7765654/
Abstract

CONTEXT

Weight regain (WR) after bariatric surgery is emerging as a common clinical problem due to the increase in the number of procedures performed. Early interventions are necessary to curtail the potential recurrence of comorbid conditions. However, it is often difficult to recognize WR early enough to introduce mitigating measures because there are no current guidelines for timely diagnosis and assessment of the severity of this condition.

OBJECTIVE

We present a practical approach for the early recognition of WR, based on 11-year follow-up data from our multiethnic bariatric surgery patient population.

METHODS

We classify WR according to the rate of increase in weight relative to nadir weight, normalized per 30-day interval. We also review pertinent literature about the etiologic factors contributing to WR after bariatric surgery.

RESULTS

According to our algorithm, mild, moderate, and rapid WR are defined as weight increases of 0.2% to <0.5%, 0.5% to 1.0%, and more than 1.0% of nadir weight per 30 days, respectively. Treatment options, including dietary counseling, use of antiobesity medication, and consideration of surgical revision, are described. A case is presented to illustrate the utility of timely identification of WR and the importance of collaboration between bariatric surgeons, obesity medicine specialists, and dietitians.

CONCLUSION

Our approach emphasizes the importance of regular long-term follow-up for all bariatric surgery patients.

摘要

背景

由于手术数量的增加,肥胖症手术后的体重反弹(WR)正成为一个常见的临床问题。为了遏制潜在的合并症复发,需要早期干预。然而,由于目前没有关于及时诊断和评估这种情况严重程度的指南,因此通常很难及早发现 WR,从而引入缓解措施。

目的

我们根据多民族肥胖症手术患者人群 11 年的随访数据,提出了一种早期识别 WR 的实用方法。

方法

我们根据体重相对于最低点的增加率对 WR 进行分类,归一化为每 30 天间隔的百分比。我们还回顾了有关肥胖症手术后导致 WR 的病因因素的相关文献。

结果

根据我们的算法,轻度、中度和快速 WR 分别定义为体重在 30 天内增加 0.2%至<0.5%、0.5%至 1.0%和超过 1.0%。描述了治疗选择,包括饮食咨询、使用减肥药和考虑手术修正。提出了一个病例来说明及时识别 WR 的效用以及肥胖症外科医生、肥胖症医学专家和营养师之间合作的重要性。

结论

我们的方法强调了对所有肥胖症手术患者进行定期长期随访的重要性。