Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Tropical Disease Research Center, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana'a, Yemen.
J Infect Dis. 2020 Oct 29;222(Suppl 8):S709-S716. doi: 10.1093/infdis/jiaa500.
The role of human mobility in the epidemiology of emerging Aedes-transmitted viral diseases is recognized but not fully understood. The objective of this systematic review and meta-analysis was to examine how human mobility patterns are driving chikungunya outbreaks.
Literature was systematically reviewed for studies on chikungunya prevalence in countries/territories with high-level evidence of human mobility-driven outbreaks, based on: (1) emergence of chikungunya outbreaks with epidemic chikungunya virus genotypes among displaced/migrant populations and their hosting communities; and (2) identification of imported index case(s) with epidemic genotypes phylogenetically related to the genotypes circulating during emerging or subsequent outbreaks.
The meta-analysis of extracted prevalence data revealed that a large proportion of the population in countries/territories afflicted by outbreaks is still at risk of infection during future outbreaks. On the other hand, approximately one-half of suspected chikungunya cases could be infected with other co-circulating acute febrile illnesses.
We discussed in this paper how human mobility-driven chikungunya outbreaks can be addressed, and how the involvement of several sectors in addition to the health sector in multisectoral approaches (MSAs) is important for prevention and control of chikungunya and other Aedes-transmitted arboviral outbreaks.
人类流动在新兴登革热传播病毒病的流行病学中的作用已得到认识，但尚未完全理解。本系统评价和荟萃分析的目的是研究人类流动模式如何推动基孔肯雅热的爆发。
根据以下两点，对具有高水平证据表明人类流动驱动暴发的国家/地区的基孔肯雅热流行情况进行了文献系统回顾：（1）在流动人口和收容社区中出现具有流行基孔肯雅病毒基因型的基孔肯雅热暴发；（2）鉴定出与正在出现或随后暴发期间流行的基因型具有系统发育关系的输入性索引病例。
提取的流行数据的荟萃分析表明，在受暴发影响的国家/地区，仍有很大一部分人口在未来暴发期间仍有感染风险。另一方面，大约有一半的疑似基孔肯雅热病例可能感染了其他同时流行的急性发热疾病。
本文讨论了如何应对由人类流动驱动的基孔肯雅热暴发，以及除卫生部门外，多个部门参与多部门措施对于预防和控制基孔肯雅热和其他登革热传播的虫媒病毒暴发的重要性。
