Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Surgery, University of Washington, Seattle, WA, USA.
Adv Exp Med Biol. 2020;1273:29-38. doi: 10.1007/978-3-030-49270-0_2.
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) of the immune system. They capture foreign antigens and can present them to lymphocytes, that is, T cells and B cells, to activate them. DCs are the most potent of all immune cells at inducing the adaptive immune system. Thus, the presence of DCs at the anatomical site of the immune challenge is imperative for the immune system to mount an effective immune response. From the anatomical site of the immune challenge, DCs cargo antigens to the draining lymph nodes, specialized immune organs where adaptive immunity is generated. DCs are heterogeneous as a type of immune cell, and various subsets of DCs have been reported and their functions described. In this chapter, we discuss various aspects of DC development and function. We further discuss how various tumor microenvironments can affect DC development, function, and migration, thus evading a strong adaptive immune response.
树突状细胞 (DCs) 是免疫系统中专业的抗原呈递细胞 (APCs)。它们捕获外来抗原，并将其呈现给淋巴细胞，即 T 细胞和 B 细胞，以激活它们。DCs 在诱导适应性免疫系统方面是最有效的免疫细胞。因此，在免疫挑战的解剖部位存在 DCs 对于免疫系统产生有效的免疫反应是至关重要的。从免疫挑战的解剖部位，DCs 将抗原运送到引流淋巴结，这是产生适应性免疫的专门免疫器官。DCs 作为一种免疫细胞具有异质性，已经报道了各种 DCs 亚群及其功能。在本章中，我们讨论了 DC 发育和功能的各个方面。我们进一步讨论了各种肿瘤微环境如何影响 DC 的发育、功能和迁移，从而逃避强烈的适应性免疫反应。
