Department of Otorhinolaryngology Head and Neck Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.
Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Medicine (Baltimore). 2024 Mar 1;103(9):e37387. doi: 10.1097/MD.0000000000037387.
Squamous cell carcinoma is seen as principal malignancy of head and neck. Tumor immune microenvironment plays a vital role in the occurrence, development and treatment of head and neck squamous cell carcinoma (HNSCC). The effect of immunotherapy, in particular, is closely related to tumor immune microenvironment. This review searched for high-quality literature included within PubMed, Web of Science, and Scopus using the keywords "head and neck cancers," "tumor microenvironment" and "immunotherapy," with the view to summarizing the characteristics of HNSCC immune microenvironment and how various subsets of immune cells promote tumorigenesis. At the same time, based on the favorable prospects of immunotherapy having been shown currently, the study is committed to pinpointing the latest progress of HNSCC immunotherapy, which is of great significance in not only further guiding the diagnosis and treatment of HNSCC, but also conducting its prognostic judgement.
鳞状细胞癌被视为头颈部的主要恶性肿瘤。肿瘤免疫微环境对头颈部鳞状细胞癌（HNSCC）的发生、发展和治疗起着至关重要的作用。免疫疗法的效果尤其与肿瘤免疫微环境密切相关。本综述通过关键词“头颈癌”、“肿瘤微环境”和“免疫疗法”，在 PubMed、Web of Science 和 Scopus 中搜索了高质量的文献，旨在总结 HNSCC 免疫微环境的特征以及各种免疫细胞亚群如何促进肿瘤发生。同时，鉴于目前免疫疗法的前景看好，本研究致力于确定 HNSCC 免疫疗法的最新进展，这不仅对头颈部鳞状细胞癌的诊断和治疗具有重要意义，而且对头颈部鳞状细胞癌的预后判断也具有重要意义。
