Prasitlumkum Narut, Chokesuwattanaskul Ronpichai, Thongprayoon Charat, Bathini Tarun, Vallabhajosyula Saraschandra, Cheungpasitporn Wisit
Department of Medicine, University of Riverside, Riverside, CA 92521, USA.
Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok 10330, Thailand.
Diseases. 2020 Oct 27;8(4):40. doi: 10.3390/diseases8040040.
The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1-23.8% with substantial heterogeneity (I = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. The incidence of COVID-19-related myocardial injury ranges from 16.1-23.8%. Further larger studies are anticipated, as the pandemic is still ongoing.
新型冠状病毒肺炎（COVID-19）感染患者中急性心肌损伤（AMI）的发生率仍不清楚。我们旨在进行一项系统评价和荟萃分析，以进一步探究这些患者中AMI的发生率。我们全面检索了MEDLINE、EMBASE和Cochrane数据库，检索时间从数据库创建至2020年8月。纳入的研究为前瞻性或回顾性队列研究，报告了COVID-19患者中AMI的事件发生率。使用随机效应合并每项研究的数据，以计算合并发生率及95%置信区间。我们纳入了27项研究，共8971例住院的COVID-19感染患者。研究表明，20.0%（95%CI 16.1-23.8%，存在高度异质性（I² = 94.9%））的住院COVID-19患者发生了AMI。此外，我们的荟萃回归分析表明，年龄较大、男性和合并症与AMI风险较高相关。COVID-19相关心肌损伤的发生率为16.1%-23.8%。由于疫情仍在持续，预计将开展进一步的大型研究。
