Howard C J, Thomas L H, Parsons K R
A.F.R.C. Institute for Research on Animal Diseases, Newbury, Berkshire, UK.
Isr J Med Sci. 1987 Jun;23(6):621-4.
Mycoplasma bovis and M. dispar are both important in the etiology of calf respiratory disease, but marked differences are evident in the pathogenesis of disease caused by the two species. Both attach to bovine cells but vary in their invasiveness. M. bovis is capable of invading the lung parenchyma from the airways, while M. dispar predominantly infects the ciliated epithelial cells lining the respiratory tract. M. dispar causes ciliostasis in fetal-bovine tracheal organ cultures, whereas M. bovis does not have the same dramatic effect on ciliary activity. The immunological response of the host contributes to the lesions produced by M. bovis. Both T- and B-lymphocytes accumulate in the lung, which becomes a site for the production of antibody. In contrast, M. dispar produces a mild cellular response in the lungs of calves and may have immunosuppressive properties.
牛支原体和副猪支原体在犊牛呼吸道疾病的病因学中都很重要，但两种菌引起的疾病发病机制存在明显差异。二者均附着于牛细胞，但侵袭性不同。牛支原体能够从气道侵入肺实质，而副猪支原体主要感染呼吸道内衬的纤毛上皮细胞。副猪支原体在胎牛气管器官培养物中可导致纤毛运动停止，而牛支原体对纤毛活动没有同样显著的影响。宿主的免疫反应会导致牛支原体产生病变。T淋巴细胞和B淋巴细胞均在肺中积聚，肺成为抗体产生的部位。相比之下，副猪支原体在犊牛肺部引起轻微的细胞反应，可能具有免疫抑制特性。
