Rickettsial Zoonoses Branch and Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Vector Borne Zoonotic Dis. 2021 Feb;21(2):125-127. doi: 10.1089/vbz.2020.2668. Epub 2020 Oct 29.
Questionnaire data have linked contact with ruminants to the risk of esophageal squamous cell carcinoma (ESCC) in high-risk Asian populations. To better understand this observed association, we investigated exposure to two major zoonotic ruminant pathogens relative to ESCC risk. Using enzyme-linked immunosorbent assay, immunofluorescence assay, and microagglutination test assays, we measured immunoglobulin G anti- and anti- spp. antibodies in patients with ESCC ( = 177) and population-based controls ( = 177) matched by age, gender, and residence area from the Golestan case-control study in Iran. We found a similarly high seroprevalence of in ESCC cases and controls (75% and 80%, respectively), and a similarly low seroprevalence of spp. (0% and 0.6%, respectively). While documenting a high exposure to one of two zoonotic ruminant infections, this exposure failed to explain the observed association of ruminant contact and ESCC risk in this high-risk population.
问卷调查数据将接触反刍动物与高危亚洲人群罹患食管鳞状细胞癌 (ESCC) 的风险联系起来。为了更好地理解这种观察到的关联，我们研究了与 ESCC 风险相关的两种主要人畜共患反刍动物病原体的暴露情况。我们使用酶联免疫吸附试验、免疫荧光试验和微凝集试验检测了伊朗戈勒斯坦病例对照研究中 ESCC 患者（n=177）和按年龄、性别和居住区域匹配的人群对照（n=177）的 IgG 抗- 和抗- spp. 抗体。我们发现 ESCC 病例和对照组的血清阳性率相似（分别为 75%和 80%），而 spp. 的血清阳性率则较低（分别为 0%和 0.6%）。虽然记录了一种人畜共患反刍动物感染的高暴露率，但这种暴露并不能解释在这一高危人群中接触反刍动物与 ESCC 风险之间的观察到的关联。
