Jin Xinhu, Liang Xinyu, Gong Gaolang
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China.
Front Neurosci. 2020 Oct 2;14:932. doi: 10.3389/fnins.2020.00932. eCollection 2020.
Functional integration among neural units is one of the fundamental principles in brain organization that could be examined using resting-state functional connectivity (rs-FC). Interhemispheric functional integration plays a critical role in human cognition. Homotopic functional connectivity (HoFC) under resting state provide an avenue to investigate functional integration between the two brain hemispheres, which can improve the present understanding of how interhemispheric interactions affect cognitive processing. In this review, we summarize the progress of HoFC studies under resting state and highlight how these findings have enhanced our understanding of interhemispheric functional organization of the human brain. Future studies are encouraged to address particular methodological issues and to further ascertain behavioral correlates, brain disease's modulation, task influence, and genetic basis of HoFC.
神经单元之间的功能整合是大脑组织的基本原理之一，可通过静息态功能连接（rs-FC）进行研究。半球间功能整合在人类认知中起着关键作用。静息状态下的同位功能连接（HoFC）为研究两个脑半球之间的功能整合提供了一条途径，这可以增进我们目前对半球间相互作用如何影响认知加工的理解。在这篇综述中，我们总结了静息状态下HoFC研究的进展，并强调了这些发现如何增进了我们对人类大脑半球间功能组织的理解。鼓励未来的研究解决特定的方法学问题，并进一步确定HoFC的行为相关性、脑部疾病的调节作用、任务影响和遗传基础。
