人类白细胞抗原系统：结构与功能
The HLA system: structure and function.
作者信息
Bodmer W F
机构信息
Imperial Cancer Research Fund, London.
出版信息
J Clin Pathol. 1987 Sep;40(9):948-58. doi: 10.1136/jcp.40.9.948.
Abstract
The HLA system is the major histocompatibility system of man and was found through a search for blood group-like determinants on white blood cells that would be effective in matching for transplantation. The HLA system has its counterparts in other species of mammals, birds, and reptiles including the much studied H2 system of the mouse. The HLA system started from a series of antigens defined by a combination of relatively crude serology and genetics, supported by extensive statistical analysis. It has turned out to be a complex genetic region determining two major sets of cell surface products which mediate essential functional interactions between cells of the immune system, and so have a major role in the control of the immune response. Polymorphism in the HLA region is thus associated with a wide variety of diseases with an immune aetiology.
摘要
HLA系统是人类的主要组织相容性系统，它是通过在白细胞上寻找类似血型的决定簇而发现的，这些决定簇在移植配型中很有效。HLA系统在其他哺乳动物、鸟类和爬行动物物种中也有对应物，包括研究很多的小鼠H2系统。HLA系统始于一系列由相对粗略的血清学和遗传学相结合定义的抗原，并得到了广泛的统计分析支持。事实证明，它是一个复杂的遗传区域，决定了两组主要的细胞表面产物，这些产物介导免疫系统细胞之间的基本功能相互作用，因此在免疫反应的控制中起主要作用。因此，HLA区域的多态性与多种具有免疫病因的疾病相关。
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