Suppr超能文献

人类白细胞抗原系统:结构与功能

The HLA system: structure and function.

作者信息

Bodmer W F

机构信息

Imperial Cancer Research Fund, London.

出版信息

J Clin Pathol. 1987 Sep;40(9):948-58. doi: 10.1136/jcp.40.9.948.

Abstract

The HLA system is the major histocompatibility system of man and was found through a search for blood group-like determinants on white blood cells that would be effective in matching for transplantation. The HLA system has its counterparts in other species of mammals, birds, and reptiles including the much studied H2 system of the mouse. The HLA system started from a series of antigens defined by a combination of relatively crude serology and genetics, supported by extensive statistical analysis. It has turned out to be a complex genetic region determining two major sets of cell surface products which mediate essential functional interactions between cells of the immune system, and so have a major role in the control of the immune response. Polymorphism in the HLA region is thus associated with a wide variety of diseases with an immune aetiology.

摘要

HLA系统是人类的主要组织相容性系统,它是通过在白细胞上寻找类似血型的决定簇而发现的,这些决定簇在移植配型中很有效。HLA系统在其他哺乳动物、鸟类和爬行动物物种中也有对应物,包括研究很多的小鼠H2系统。HLA系统始于一系列由相对粗略的血清学和遗传学相结合定义的抗原,并得到了广泛的统计分析支持。事实证明,它是一个复杂的遗传区域,决定了两组主要的细胞表面产物,这些产物介导免疫系统细胞之间的基本功能相互作用,因此在免疫反应的控制中起主要作用。因此,HLA区域的多态性与多种具有免疫病因的疾病相关。

相似文献

1
The HLA system: structure and function.
J Clin Pathol. 1987 Sep;40(9):948-58. doi: 10.1136/jcp.40.9.948.
8
[The HLA gene complex].
Infusionsther Transfusionsmed. 1994 Jun;21(3):185-91.
9
Human leukocyte antigen and its role in transplantation biology.
Transplant Proc. 2007 Apr;39(3):688-93. doi: 10.1016/j.transproceed.2007.01.066.
10
HLA serology--1983.
Prog Clin Biol Res. 1984;149:207-20.

引用本文的文献

1
Recent advances in the genetics and innate immune cells of bullous pemphigoid.
Front Immunol. 2025 Jun 18;16:1530407. doi: 10.3389/fimmu.2025.1530407. eCollection 2025.
2
Epstein-Barr virus: the mastermind of immune chaos.
Front Immunol. 2024 Feb 7;15:1297994. doi: 10.3389/fimmu.2024.1297994. eCollection 2024.
3
The role of HLA genetic variants in COVID-19 susceptibility, severity, and mortality: A global review.
J Clin Lab Anal. 2024 Jan;38(1-2):e25005. doi: 10.1002/jcla.25005. Epub 2024 Jan 22.
4
Uncovering the Underworld of Axial Spondyloarthritis.
Int J Mol Sci. 2023 Mar 30;24(7):6463. doi: 10.3390/ijms24076463.
5
Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing.
Sci Rep. 2019 May 30;9(1):8067. doi: 10.1038/s41598-019-44336-7.
6
Tubulointerstitial Nephritis and Uveitis Syndrome: Are Drugs Offenders or Bystanders?
Clin Med Insights Case Rep. 2016 Mar 16;9:21-4. doi: 10.4137/CCRep.S36862. eCollection 2016.
8
Constraints on haplotype structure and variable gene frequencies suggest a functional hierarchy within cattle MHC class I.
Immunogenetics. 2012 Jun;64(6):435-45. doi: 10.1007/s00251-012-0612-6. Epub 2012 Mar 28.
9
Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies.
Cancer Immunol Immunother. 2011 Aug;60(8):1127-35. doi: 10.1007/s00262-011-0985-7. Epub 2011 Apr 9.
10
HLA class-II allele frequencies in Turkish breast cancer patients.
Med Oncol. 2012 Jun;29(2):466-71. doi: 10.1007/s12032-011-9873-4. Epub 2011 Mar 4.

本文引用的文献

1
A NEW LEUKOCYTE ISOANTIGEN SYSTEM IN MAN.
Cold Spring Harb Symp Quant Biol. 1964;29:285-95. doi: 10.1101/sqb.1964.029.01.031.
2
Study of the HLA system in Burkitt's lymphoma.
Hum Immunol. 1980 Oct;1(3):207-10. doi: 10.1016/0198-8859(80)90015-4.
4
6
The detailed distribution of MHC Class II antigens in normal human organs.
Transplantation. 1984 Sep;38(3):293-8. doi: 10.1097/00007890-198409000-00019.
7
The detailed distribution of HLA-A, B, C antigens in normal human organs.
Transplantation. 1984 Sep;38(3):287-92. doi: 10.1097/00007890-198409000-00018.
8
A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system.
Tissue Antigens. 1984 Oct;24(4):234-46. doi: 10.1111/j.1399-0039.1984.tb02132.x.
10
HLA and disease 1982--a survey.
Immunol Rev. 1983;70:193-218. doi: 10.1111/j.1600-065x.1983.tb00715.x.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验